[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 9, Issue 2 (9-2010) ::
3 2010, 9(2): 96-0 Back to browse issues page
Antidiarrhoeal and Antiulcer Activities of Mammea Africana
J. Efiom Okokon , E. E. Umoh , F. U. Umoh , E. I. Etim
Abstract:   (1230 Views)
The   stembark of Mammea africana is used traditionally for the treatment of stomach pains. The present study was designed to evaluate the effects of ethanolic stembark extract of Mammea africana on experimentally induced diarrhoea and ulcer . The extract ( 30 – 90mg/kg) was administered orally in rats 30 minutes to one hour before the induction of diarrhoeal and ulcer using different experimental models. Castor oil (2ml) was used to induce diarrhoea, while indomethacin (60mg/kg) and ethanol (2.5ml/kg) were used to induce ulcers in rats. F requency of defecation , inhibition of intestinal propulsion and fluid accumulation were measured in the case of diarrhoea and ulcer index were calculated to examine ulcer preventive ratio of the extract. The extract ( 3 0 – 9 0mg/kg) significantly   inhibited   castor oil induced diarrhoea, small intestine transit time and castor oil induced fluid accumulation as well as indomethacin and ethanol induced ulcer models. The effect of the extract in th ese models was un comparable to the various standard drugs used. These findings justify the use of this stembark traditionally in the treatment of stomach pains and disorders.
Full-Text [PDF 182 kb]   (678 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Okokon J E, Umoh E E, Umoh F U, Etim E I. Antidiarrhoeal and Antiulcer Activities of Mammea Africana. 3 2010; 9 (2) :96-0
URL: http://ijpt.iums.ac.ir/article-1-205-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 9, Issue 2 (9-2010) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.06 seconds with 39 queries by YEKTAWEB 4642