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The Involvement of Non Opioidergic Mechanism in the Antinociceptive and Antilocomotive Activity of Bacopa monnieri
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Muzaffar Abbas   , Fazal Subhan , Khalid Rauf , Ikram Ul-Haq , Syed Nadeem-ul-Hassan Mohani |
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Abstract: (1397 Views) |
| A hydroethanolic extract (HE-ext) of Bacopa monnieri (BM) was studied for antinociceptive effect in the animal models of acetic-acid-induced writhing test and antilocomotive effect in mice. Standard centrally-acting analgesic, morphine (MP), and peripherally-acting one, diclofenac (Diclo), were also tested along with the extract for comparison. The extract exhibited significant antinociceptive effect ( p < 0.001) in this test, not antagonized by the opioid receptor antagonist, naloxone (NLX) in a fashion similar to diclofenac. This excluded the involvement of opioids in the mediation of antinociceptive response of Bacopa monnieri . Moreover, the BM HE-ext exhibited highly significant antilocomotive ( p < 0.0001) that was also unaffected by naloxone. These results indicate that Bacopa monnieri possesses antinociceptive and antilocomotive effect that may be mediated through non-opioidergic mechanism. |
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Article Type: Research Article |
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