[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 11, Issue 1 (10-2012) ::
3 2012, 11(1): 15-0 Back to browse issues page
The Involvement of Non Opioidergic Mechanism in the Antinociceptive and Antilocomotive Activity of Bacopa monnieri
Muzaffar Abbas , Fazal Subhan , Khalid Rauf , Ikram Ul-Haq , Syed Nadeem-ul-Hassan Mohani
Abstract:   (1202 Views)
A hydroethanolic extract (HE-ext) of Bacopa monnieri (BM) was studied for antinociceptive effect in the animal models of acetic-acid-induced writhing test and antilocomotive effect in mice. Standard centrally-acting analgesic, morphine (MP), and peripherally-acting one, diclofenac (Diclo), were also tested along with the extract for comparison. The extract exhibited significant antinociceptive effect ( p < 0.001) in this test, not antagonized by the opioid receptor antagonist, naloxone (NLX) in a fashion similar to diclofenac. This excluded the involvement of opioids in the mediation of antinociceptive response of Bacopa monnieri . Moreover, the BM HE-ext exhibited highly significant antilocomotive ( p < 0.0001) that was also unaffected by naloxone. These results indicate that Bacopa monnieri possesses antinociceptive and antilocomotive effect that may be mediated through non-opioidergic mechanism.
Full-Text [PDF 357 kb]   (666 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Abbas M, Subhan F, Rauf K, ul-Haq I, Mohani S N. The Involvement of Non Opioidergic Mechanism in the Antinociceptive and Antilocomotive Activity of Bacopa monnieri. 3 2012; 11 (1) :15-0
URL: http://ijpt.iums.ac.ir/article-1-237-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 11, Issue 1 (10-2012) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4642