[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 4, Issue 2 (11-2005) ::
3 2005, 4(2): 91-0 Back to browse issues page
Pharmacokinetic Studies of Enrofloxacin in Yak after Intramuscular Administration
Sanjib Khargharia , Chandana Choudhury Barua , Pritam Mohan , Mohan Bhattacharya
Abstract:   (1449 Views)
The pharmacokinetic studies of enrofloxacin were investigated in yak (Bos grunniens L.) after administration of enrofloxacin by intramuscular route at 5 mgkg-1 body weight. Blood samples were collected from the jugular vein at predetermined time intervals after drug administration. Plasma was separated and analysed for enrofloxacin by reverse-phase high performance liquid chromatography. Various pharmacokinetic parameters were calculated using a non-compartmental model. The elimination half-life (t), area under plasma concentration-time curve (AUC), area under the moment curve (AUMC), mean residence time (MRT), apparent volume of distribution (Vd), total body clearance (ClB) and apparent first-order elimination rate constant (K) of enrofloxacin were 2.790.60 h, 5.351.29 ghmL-1, 21.508.60 gh2mL-1, 4.020.87 h, 3.760.83 Lkg-1, 935.09236.45 mLh-1kg-1 and 0.250.07 h-1, respectively after the administration of enrofloxacin. Because of faster elimination time, excellent tissue penetration, shorter half-life, low MRT after intramuscular administration of enrofloxacin at a dose rate of 5 mgkg-1, it is recommended for use in yaks at therapeutic dose.
Full-Text [PDF 354 kb]   (717 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khargharia S, Choudhury Barua C, Mohan P, Bhattacharya M. Pharmacokinetic Studies of Enrofloxacin in Yak after Intramuscular Administration. 3 2005; 4 (2) :91-0
URL: http://ijpt.iums.ac.ir/article-1-65-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 4, Issue 2 (11-2005) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4657