[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 1, Issue 2 (11-2002) ::
3 2002, 1(2): 39-0 Back to browse issues page
Study of Serum and Tissues Angiotensin Converting Enzyme (ACE) Activity in Rat with Gentamicin Induced Renal Toxicity
Seyed Ali Ziai, Pirooz Salehian, Massoud Mahmoudian
Abstract:   (1057 Views)
The angiotensin I-converting enzyme (ACE) converts the inactive angiotensin I molecule to the active angiotensin II. ACE is rich in epithelium, endothelium, and neuroepithelial cells and it found largely on the brush border of intestine and kidney proximal tubules. ACE also presents in the serum. Some pulmonary and renal toxic drugs change the serum and tissue ACE contents. In this research ACE activity was studied in rats with gentamicin induced renal toxicity. Rats were sacrificed 1, 3, 5 and 7 days after gentamicin injection. ACE activity was measured in serum, kidney and lung. These data were compared with normal saline-treated rats. Treatment of rats with gentamicin results in renal damage evidenced by proteinuria, polyuria, and decreased creatinine clearance. The damage to the kidney proximal tubule was evident by (a) the histological analysis at light microscopy and (b) the augmentation in the urinary excretion of N-acetyl-?-D-glucosaminidase (NAG). Kidney ACE activity decreased and lung and serum ACE activity didn’t change until day 7. Then lung ACE activity increased significantly at day 7 and kidney and serum ACE activity increased, too. Blood pressure increased significantly on the day 7 that corresponded with the lung ACE activity increment. These data suggest that kidney ACE activity decrease are due to renal damage and an universal signal increases the ACE contents in the body probably to increase systemic blood pressure and subsequently increase glomerular filtration rate (GFR).
Full-Text [PDF 57 kb]   (466 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ziai S A, Salehian P, Mahmoudian M. Study of Serum and Tissues Angiotensin Converting Enzyme (ACE) Activity in Rat with Gentamicin Induced Renal Toxicity. 3 2002; 1 (2) :39-0
URL: http://ijpt.iums.ac.ir/article-1-6-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 1, Issue 2 (11-2002) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.07 seconds with 32 queries by YEKTAWEB 4610