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:: Volume 17, Issue 1 (6-2019) ::
3 2019, 17(1): 1-11 Back to browse issues page
Relaxant effect of pioglitazone on the guinea-pig isolated trachea through the modulation of endogenous prostaglandins
HITEC Institute of Medical Sciences, National University of Medical Sciences, Rawalpindi, Pakistan
Abstract:   (2192 Views)
Thiazolidinediones are commonly used anti-diabetic drugs. Owing to the anti-inflammatory action of TZDs as a result of there action on the PPAR gamma receptor and a proposed action on the prostaglandins, these drugs can be tried in the acute exacerbations of COPD that are also commonly found among diabetic patients. An experimental study of one week was carried out at animal house of Army Medical College, Rawalpindi on a total of 50 guinea pigs (both male and female) of Dunkin Hartley variety, weighing 500 to 600 grams. An isometric volume transducer was used to measure the histamine induced contractions of the smooth muscles. In the similar way contractions with pioglitazone in the presense of histamine, contractions with indomethacin which is a prostaglandin antagonist, in the presence of histamine and mixed effect of pioglitazone along with indomethacin in the presence of histamine was evaluated. Pioglitazone produced significant reduction in histamine-induced contractions of the normal tracheal muscle strips thus identifying its relaxant effect on the tracheal smooth muscles. The contractions of the tracheal muscles were increased when indomethacin was used. The pioglitazone induced relaxation was also reduced in the group pre-treated with indomethacin, thus suggesting an identifiable role of prostaglandins in the relaxant effect of TZDs on the smooth muscles
Keywords: Thiazolidinediones, COPD, Prostaglandins
Full-Text [PDF 838 kb]   (639 Downloads)    
Article Type: Research Article | Subject: Endocrine and Reproductive
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ABRAR N, JANJUA A, JAHAN S, KHAN M, ZAHID S, KHAN A. Relaxant effect of pioglitazone on the guinea-pig isolated trachea through the modulation of endogenous prostaglandins. 3 2019; 17 (1) :1-11
URL: http://ijpt.iums.ac.ir/article-1-372-en.html

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Volume 17, Issue 1 (6-2019) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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