[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 17, Issue 1 (6-2019) ::
3 2019, 17(1): 1-7 Back to browse issues page
Chemical characterization and anti-parasitic property of essential oil of Coriandrum sativum leaf against Trichomonas vaginalis
Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Abstract:   (2514 Views)
Coriandrum sativum has been used in Iranian traditional medicine as an anti-inflammatory, antioxidant, antibacterial, and antifungal agent. The purpose of this study was to evaluate the chemical composition and anti-parasitic property of essential oil of C. sativum leaf on trophozoite of Trichomonas vaginalis. C. sativum was collected from Kermanshah city and essential oil was prepared by the Clevenger device. The essential oil was analyzed by GC/MS. Trophozoite of T. vaginalis was cultured in vitro in CPLM medium and the effect of the essential oil on the survival of T. vaginalis trophozoite was measured by Neobar slide. This study indicated that Linalool (71.2%) was the most constituent found in C. sativum essential oil. Also, the results of anti-parasitic tests demonstrated the concentrations of 0.5, 0.25, 0.125, 0.062, 0.031, 0.015, 0.007, 0.003, and 0.001 g/ml in essential oil and 0.25 g/ml in metronidazole could destroy of T. vaginalis trophozoite completely after 420 minutes incubation. The best results were observed at 0.5 and 0.25 g/ml concentrations of essential oil, because these concentrations were able to destroy trophozoite in 90 minutes. Also, 0.001 g/ml concentration of essential oil had the lower anti-parasitic effect than all concentrations against T. vaginalis trophozoite. The trophozoite survived at DMSO after 600 minutes. MIC and MLC of C. sativum essential oil were 0.015 and 0.031 g/ml concentrations, respectively. In our study, the essential oil of C. sativum leaf in several concentrations destroyed T. vaginalis trophozoite. It appears that C. sativum can be used for the treatment of some T. vaginalis infections as an antibiotic.
Keywords: Coriandrum sativum, Essential oil, Chemical characterization, Anti-parasitic property, Trichomonas vaginalis
Full-Text [PDF 425 kb]   (668 Downloads)    
Article Type: Research Article | Subject: Other
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

CHALECHALE A, ZANGENEH M M, ZANGENEH A, HAMZAVI Y, VALADKHANI Z. Chemical characterization and anti-parasitic property of essential oil of Coriandrum sativum leaf against Trichomonas vaginalis. 3 2019; 17 (1) :1-7
URL: http://ijpt.iums.ac.ir/article-1-334-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 17, Issue 1 (6-2019) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.06 seconds with 39 queries by YEKTAWEB 4657