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Combination drugs therapy delays diabetic induced cognitive impairment
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TENZIN TENDER *   , SR MUBEENA |
| Al-Ameen College of Pharmacy, Rajiv Gandhi University of health Science, Bangalore, India |
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Abstract: (3048 Views) |
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Presently drugs that are available to treat the diabetic induced cognitive impairment presents adverse effect on long term used. This study offers evidence that old drugs can be combined and used. Existing and affordable drugs can be repurposed and can benefit patients .The study used a combination of drugs with proven safety for preventing/delaying the development of cognitive impairment in diabetes with a hope to improve the quality of life of diabetic patients.In current study diabetic rats were treated for eight weeks with combination of gamma linolenic acid (30mg/kg,p.o), alpha lipoic acid (30mg/kg,p.o), phloroglucinol (250mg/kg,p.o) l-thyroxine (1mg/kg, s.c) in one group and combination of of gamma linolenic acid (30mg/kg,p.o), alpha lipoic acid (30mg/kg,p.o), allantoin (200mg/kg,p.o), l-thyroxine (1mg/kg,s.c) in other group.The degree of preventative was determined by various parameters like body weight, measurement of neurotransmitter and calculating glycosylated haemoglobin and behavioural studies to check whether combination therapy has positive impact on diabetic induced cognitive impairment.
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| Keywords: Keywords- Gamma linolenic acid, Alpha lipoic acid, Phloroglucino, Allantoin, l-thyroxine |
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Full-Text [PDF 608 kb]
(866 Downloads)
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Article Type: Research Article |
Subject:
Endocrine and Reproductive
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