[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 15, Issue 1 (6-2017) ::
3 2017, 15(1): 1-4 Back to browse issues page
Evaluation of skeletal muscle relaxant activity of quercetin and chrysin in Albino rats using rota-rod apparatus and actophotometer
Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India
Abstract:   (2028 Views)

Quercetin is a natural flavonoid found abundantly in vegetables and fruits. Chrysin (5, 7-dihydroxyflavone), a natural polyphenol, occurs in many plants, honey, and propolis. Quercetin and chrysin have a blend of many pharmacological activities such as anticarcinogenic, pro-apoptotic, antiangiogenic, antimetastatic, immunomodulatory, and antioxidant properties. But there is no scientific evidence regarding the muscle relaxant activity and locomotor activities of selected flavonoids. The present study was planned to evaluate the influence of quercetin and chrysin on muscle relaxant and locomotor activities using experimental animal models. Quercetin and chrysin (20, 40 and 60 mg/kg) was administered to rats and evaluated for muscle relaxant activity using rota-rod apparatus and locomotor activity using actophotometer. The time spent on the rota rod was significantly reduced by chrysin at 20, 40 and 60 mg/kg when compared to saline (control). Quercetin also reduced the time spent but statistically not significant. The positive control, diazepam was found to be more significant (p< 0.001) than the test doses of chrysin. The results of the locomotor activity study indicated that chrysin significantly reduced the locomotion in rats, but quercetin has no significant activity. The results of the present study revealed the chrysin has significant (p< 0.001) and dose dependent muscle relaxant and locomotor depressant activities. Quercetin also reduced the muscle relaxant and locomotor activities but statistically not significant.

Keywords: Actophotometer, Rotarod apparatus, Quercetin, Chrysin, Locomotor activity
Full-Text [PDF 337 kb]   (2151 Downloads)    
Article Type: Research Article | Subject: Neuropharmacology
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

REDDY D, SHINDEY S, KILARU N B, PINGILI R. Evaluation of skeletal muscle relaxant activity of quercetin and chrysin in Albino rats using rota-rod apparatus and actophotometer. 3 2017; 15 (1) :1-4
URL: http://ijpt.iums.ac.ir/article-1-309-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 15, Issue 1 (6-2017) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.07 seconds with 39 queries by YEKTAWEB 4642