[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 3, Issue 1 (5-2004) ::
3 2004, 3(1): 21-0 Back to browse issues page
Derivative Spectrophotometric Method for Determination of Losartan in Pharmaceutical Formulations
Mehdi Ansari , Maryam Kazemipour , Mehdi Baradaran , Hassan Jalalizadeh
Abstract:   (1949 Views)
Losartan, a highly effective blood pressure lowering agent, has been widely used for the treatment of hypertension. A fast and reliable method for the determination of losartan was highly desirable to support formulation screening and quality control. A first derivative UV spectroscopic method was developed for determination of losartan in the tablet dosage form. The first derivative spectrum recorded between 220 and 320 nm, and a zero-crossing technique for first derivative measurement at 232.5 nm was selected. It is found that the selectivity and sensitivity of method to be in desirable range. In comparison with the direct UV method, the first derivative UV spectroscopy has a definite through without any interference from UV absorbing excipients. This method is also fast and economical in comparison to the more time-consuming HPLC method regularly used for formulation screening and quality control and can be used routinely by any laboratory possessing a spectrophotometer with a derivative accessory. The linear concentration ranges were 2-50 ?g/mL, (Dl = -0.0159C - 0.0056, r =0.9994, n=6). Between days CV% 2.9, within day CV% 2.1, analytical recovery close to 98.1 % shows the suitability of the method for determination in quality control.
Full-Text [PDF 427 kb]   (2344 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ansari M, Kazemipour M, Baradaran M, Jalalizadeh H. Derivative Spectrophotometric Method for Determination of Losartan in Pharmaceutical Formulations. 3 2004; 3 (1) :21-0
URL: http://ijpt.iums.ac.ir/article-1-28-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3, Issue 1 (5-2004) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.06 seconds with 39 queries by YEKTAWEB 4657