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Niacin Exacerbates Methyl Prednisolone-Induced Bone Changes in Growing Rats
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Tahoora Shomali   , Mina Tadjalli , Reza Akhavan Taheri |
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Abstract: (1531 Views) |
| Positive role of niacin on serum lipid profile of rats treated with glucocorticoids (GCs) has been reported. This study aims to evaluate effect of niacin on bone changes in GC-induced dyslipidemic rats. A number of 28 growing rats divided into four groups and treated as control, Methyl prednisolone (MP) group (3.5 mg/kg five days a week, SC); MPN group (MP + niacin 200 mg/kg/day orally) and MPA group (MP + alendronate 0.03 mg/kg/day, SC). After 4 weeks, serum lipid profile and histomorphometric parameters including trabecular width (Tb.Wi), trabecular separation (Tb.Sp) and number (Tb.N), bone area/tissue area (B.Ar/T.Ar) and osteoid thickness (O.Th) in metaphyseal side of growth plate of femoral head were determined. Obvious dyslipidemia and decreased B.Ar/T.Ar and O.Th were observed in MP group. Niacin alleviated dyslipidemia, however MPN rats had appreciably lower Tb.N and higher Tb.Sp as compared to MP group. Alendronate had a moderate positive effect on bone changes. Although niacin effectively ameliorates GC-induced dyslipidemia in growing rats, it may exacerbate bone changes. |
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Article Type: Research Article |
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