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Cystone, a well-known herbal formulation improves renal function in rats with acute renal failure (ARF) induced by Glycerol intoxication
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M. Rafiq   , G. L. Viswanatha , M. Mohammed Azeemuddin , D. A. Suryakanth , V. K. Uday Kumar , P. S. Patki |
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Abstract: (2202 Views) |
| The present study was aimed to evaluate the beneficial effect of Cystone syrup in an experimental model of glycerol-induced acute renal failure (ARF) in rats. Biochemical parameters, kidney weight and histopathological evaluation were performed to conclude the beneficial effect of Cystone syrup. Administration of single dose of 50% v/v glycerol (8ml/kg.i.m) caused severe renal dysfunction associated with significant increase in markers of renal function such as serum urea ( p <0.01), creatinine ( p <0.01), blood urea nitrogen (BUN) ( p <0.01), decrease in the Creatinine clearance (Ccr) ( p <0.01) and increase in kidney weight to body weight ratio ( p <0.01) compared to control group. These changes were in accordance with the histopathological findings showing severe tubular necrosis, degeneration and moderate luminal cast formation. In contrast, pre-treatment with Cystone (5 ml/kg, p .o) for seven days, alleviated the glycerol induced renal dysfunction significantly by maintaining serum urea ( p <0.01), creatinine ( p <0.05), BUN ( p <0.01) and kidney weight to body weight ratio ( p <0.05) near to normal range, also improved the creatinine clearance ( p <0.05) compared to untreated positive control. In addition, histopathology of Cystone (5 ml/kg, p.o) treated group showed mild to moderate tubular necrosis and degeneration. Thus, the findings of the present study demonstrates the usefulness of Cystone syrup in reversing the biochemical/ structural markers of renal dysfunction observed in experimental model of renal failure in rats. |
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Article Type: Research Article |
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