[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 10, Issue 1 (1-2011) ::
3 2011, 10(1): 21-0 Back to browse issues page
Protective Effect of Methanolic Leaf Extract of Caesalpinia Bonduc (L.) on Gentamicin-Induced Hepatotoxicity and Nephrotoxicity in Rats
A. Ali Noorani , K. Gupta , K. Bhadada , M. K. KALE
Abstract:   (2149 Views)
The present study was conducted to evaluate the protective effect of methanolic leaf extract of Caesalpinia bonduc (L.) on gentamicin-induced hepatotoxicity and nephrotoxicity in rats . A control group (saline, group I, n = 6) was compared with rats administrated 80 mg/kg gentamicin, once daily for 7 days (groups II, III and IV). The effect of methanolic leaf extract of Caesalpinia bonduc (group III and IV) at a dose level of 250 mg/kg and 500 mg/kg was compared in gentamicin-induced hepatotoxicity and nephrotoxicity. The activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), bilirubin, and total protein the values of urea, sodium, potassium and chloride were significantly increased in rats exposed to gentamicin. Moreover, administration of gentamicin resulted in damage to liver and kidney structures. Administration of methanolic extract of C.bonduc before gentamicin exposure prevented severe alterations of biochemical parameters and disruptions of liver and kidney structures. In conclusion, this study obviously demonstrated that pretreatment with methanolic extract of C.bonduc significantly attenuated the physiological and histopathological alterations induced by gentamicin. Also, the present study identifies new areas of research for development of better therapeutic agents for liver, kidney, and other organs dysfunctions and diseases.
Full-Text [PDF 233 kb]   (1915 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Noorani A A, Gupta K, Bhadada K, KALE M K. Protective Effect of Methanolic Leaf Extract of Caesalpinia Bonduc (L.) on Gentamicin-Induced Hepatotoxicity and Nephrotoxicity in Rats. 3 2011; 10 (1) :21-0
URL: http://ijpt.iums.ac.ir/article-1-220-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 1 (1-2011) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.06 seconds with 39 queries by YEKTAWEB 4657