[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 10, Issue 1 (1-2011) ::
3 2011, 10(1): 17-0 Back to browse issues page
Pharmacokinetics and dosage regimen of cefpirome in febrile cross-bred calves
N. Rajput , V. Kumar Dumka , Harpal Singh Sandhu
Abstract:   (1235 Views)
The pharmacokinetics of cefpirome after a single intravenous injection of 10 mg.kg -1 was studied in febrile cross-bred calves. E. coli endotoxin was administered intravenously to induce fever in calves. Blood samples were collected at different time intervals and cefpirome levels were estimated by using microbiological assay technique. Based on the plasma drug levels, the pharmacokinetic parameters were determined. Maximum concentration of cefpirome was attained at 1 min and the drug was detected above MIC in plasma up to 12 h after its administration. The values of t 1/2? , Vd area and AUC were 0.06 ± 0.003 h, 0.75 ± 0.02 L.kg -1 and 36.6 ± 0.82 ?g.ml -1 .h. The high values of t 1/2? (1.90 ± 0.03 h) and Cl B (0.27 ± 0.006 L.kg -1 .h -1 ) reflected rapid elimination and body clearance of the drug in febrile calves. The study suggested that cefpirome was rapidly distributed and rapidly eliminated in febrile crossbred calves.
Full-Text [PDF 163 kb]   (882 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rajput N, Dumka V K, Sandhu H S. Pharmacokinetics and dosage regimen of cefpirome in febrile cross-bred calves. 3 2011; 10 (1) :17-0
URL: http://ijpt.iums.ac.ir/article-1-219-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 1 (1-2011) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.07 seconds with 39 queries by YEKTAWEB 4642