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H2S: an Endogenous Gas
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Patel manish Amrutlal   , Shah gaurang B |
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Abstract: (1358 Views) |
| Gases such as NO and CO play important roles both in normal physiology and in disease. In recent years, interest has been directed towards other naturally occurring gases, notably H 2 S, which is produced in body by three enzymes namely CBS (cystathionine beta synthase), CSE (cystathionine gamma lyase) and MST (3-Mercaptopyruvate sulfurtransferase), present in mitochondria and/or cytosols where main substrate is L-cysteine. Recent studies have shown that vascular tissues generate measurable amount of H2S. NO is considered as inducer for H2S. H 2 S has gained importance as a neuromodulator and a vasorelaxant factor and as the first endogenous gaseous ATP dependant K + channel opener. It potentiates LTP by enhancing NMDA induced inward current.H 2 S induces vasorelaxation, inhibits insulin secretion and also has a role in inflammation. H 2 S also appear to have a role in neuroendocrine fuction because it plays an important role in control of the hypothalamus-pitutary-adrenal axis, inhibit stimulated release of corticotropin-releasing hormone. H 2 S has been found to be decreased in patient with Alzheimer’s disease and higher concentrations are found in patients with Down’s syndrome. It has a role in development of hypertension, suggesting its role in CNS and CVS disorders. H 2 S it is well known toxic gas with the smell of rotten eggs, is now proposed as a physiologically important molecule. |
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Full-Text [PDF 351 kb]
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Article Type: Research Article |
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