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Effects of Methanolic Extract of Oxystelma esculentum on Diuresis and Urinary Electrolytes Excretion in Rats
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Ashokkumar Durairaj   , Upal Kanti Mazumder , Malaya Gupta , Subrata Kumar Ray |
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Abstract: (1676 Views) |
| The diuretic activity of methanol extract of Oxystelma esculentum aerial parts (MEOE) was studied in male Wister albino rats at 5h and 24h interval. The animals were divided into 5 groups: control, urea, furosemide and 200mg/kg and 400mg/kg MEOE. The extract was administered intraperitoneally (i.p) pretreated and all animals were saline MEOE. The urine volume (in mL) and electrolytes excretion (Na + , K + , Ca 2+ and Cl - ) at 5h and 24h duration were measured. The urine output increased significantly in urea, furosemide and both MEOE groups ( p <0.001). MEOE increased the urine volume and electrolytes balance in a dose dependent manner. The results indicate that MEOE is an effective hypernatramic, hyperkalaemic, hypercalcemic and hyperchloremic diuretic, which supports the traditional claim about the Oxystelma esculentum being used as a diuretic. |
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Article Type: Research Article |
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