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:: Volume 5, Number 2 (12-2006) ::
3 2006, 5(2): 175-0 Back to browse issues page
Bioactive Alkaloid from Sida cordifolia Linn. with Analgesic and Anti-Inflammatory Activities
Ranajit Kumar Sutradhar, AKM Matior Rahman, Mesbahuddin Ahmad, Sitesh Chandra Bachar, Achinto Saha, Samar Kumar Guha
Abstract:   (1 Views)
In the present study, the analgesic and anti-inflammatory activities of a new alkaloid (5&prime;-Hydroxymethyl-1&prime;-(1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin-1-yl)-heptan-1-one) (compound 1), isolated from Sida cordifolia Linn. was investigated in animal models. The analgesic activity was investigated in the acetic acid induced writhing and the radiant heat tail flick model in mice and the carrageenan induced rat paw edema model was used for anti-inflammatory study. The compound produced significant ( p <0.01) analgesic activity in both models. The compound also exhibited significant ( p <0.01) inhibition of rat paw edema induced by carrageenan. These results indicated that compound 1 possessed analgesic and anti-inflammatory activities .
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Article Type: Research Article |
Received: 2017/11/13
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Sutradhar R K, Rahman A M, Ahmad M, Bachar S C, Saha A, Kumar Guha S. Bioactive Alkaloid from Sida cordifolia Linn. with Analgesic and Anti-Inflammatory Activities. 3. 2006; 5 (2) :175-0
URL: http://ijpt.iums.ac.ir/article-1-86-en.html
Volume 5, Number 2 (12-2006) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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