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:: Volume 5, Number 1 (9-2006) ::
3 2006, 5(1): 77-0 Back to browse issues page
Analgesic, Anti-Inflammatory and Ulcerogenic Studies of Meloxicam Solid Dispersion in Rodents
Sengodan Gurusamy Vijaya Kumar, Dina Nath Mishra
Abstract:   (3 Views)
Meloxicam is a non steroidal anti-inflammatory drug, used in the treatment of rheumatoid arthritis and oestoarthritis. It is practically insoluble in water leading to poor dissolution, variations in bioavailability and gastric irritation on oral administration. In order to modulate its gastric side effect and to increase aqueous solubility, physical mixture and solid dispersion of the drug were prepared with polyethylene glycol 6000 and polyvinyl pyrrolidine. The analgesic, anti-inflammatory and ulcerogenic effects were assessed for physical mixture and solid dispersion in comparison with meloxicarn alone. The results indicate that both physical mixture and solid dispersion possess better analgesic and anti-inflammatory properties with less ulcerogenic potential as compared to pure meloxicam.
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Article Type: Research Article |
Received: 2017/11/13
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Vijaya Kumar S G, Mishra D N. Analgesic, Anti-Inflammatory and Ulcerogenic Studies of Meloxicam Solid Dispersion in Rodents. 3. 2006; 5 (1) :77-0
URL: http://ijpt.iums.ac.ir/article-1-72-en.html
Volume 5, Number 1 (9-2006) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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