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:: Volume 15, Issue 1 (6-2017) ::
3 2017, 15(1): 1-4 Back to browse issues page
Preventive effects of hydroalcoholic extract of Passiflora incarnata on morphine withdrawal syndrome and its comparison with clonidine in mice
MAJID MOTAGHINEJAD, MANIJEH MOTEVALIAN, OZRA MOTAGHINEJAD
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran, Department of pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (404 Views)
Chronic use of morphine lead to dependence and discontinuation of the drug causes physical and emotional changes which needs pharmacological intervention. In the present study, the preventive effects of various doses of Passiflora incarnata extract on morphine withdrawal syndrome was evaluated in comparison to clonidine as a standard method. Total withdrawal score (TWS) was calculated based on behavioral sign of naloxone precipitated withdrawal syndrome in 56 adult male mice divided in 7 groups; in 6 groups morphine dependency was induced by chronic injection of morphine for 6 consecutive days. Passiflora incarnata hydro alcoholic extract was administered in doses 100, 200, 400, 800 mg/kg. Clonidine and normal saline were used in the control group. Withdrawal syndrome was induced by injection of naloxone. Total withdrawal score was decreased by chronic administration of Passiflora incarnata and clonidine. This study showed that clonidine (0.4mg/kg i.p.) and Passiflora incarnata extract significantly decrease TWS in the all used doses and in comparison to normal saline with a preventive effect comparable to clonidine. The data obtained in this study suggest Passiflora incarnata hydro-alcoholic extract therapeutic potential in prevention and management of opiate withdrawal syndrome which is comparable to the effect of clonidine, particularly at high doses of the plant extract.
Keywords: Passiflora incarnata, Morphine, Withdrawal syndrome prevention, Clonidine
Full-Text [PDF 520 kb]   (120 Downloads)    
Article Type: Research Article | Subject: Neuropharmacology
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MOTAGHINEJAD M, MOTEVALIAN M, MOTAGHINEJAD O. Preventive effects of hydroalcoholic extract of Passiflora incarnata on morphine withdrawal syndrome and its comparison with clonidine in mice. 3. 2017; 15 (1) :1-4
URL: http://ijpt.iums.ac.ir/article-1-347-en.html


Volume 15, Issue 1 (6-2017) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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