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:: Volume 9, Issue 1 (1-2010) ::
3 2010, 9(1): 11-0 Back to browse issues page
Antinociceptive Activity of Mimosa pudica Linn
M. Karthikeyan , M. K. Deepa
Abstract:   (204 Views)
Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:&quot;Table Normal&quot;; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:&quot;&quot;; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:&quot;Times New Roman&quot;; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Mimosa pudica Linn (Mimisoideae) is a plant used in traditional medicine for various disorders. The aim of this work was to evaluate the acute toxicity and antinociceptive activity of the aqueous extract of Mimosa pudica in animal models. In the acute toxicity study, a single dose of aqueous extract of 2000 mg kg -1 body weight p.o. was administered. For 48 h, animals showed no clinical signs and mortality. In the acetic acid-induced writhing model, the extract at a dose of 200 & 400 mg kg -1 body weight showed significant ( p <0.001) inhibition of writhing response of 46.24 and 56.0 % respectively. In the hot plate test, the extract produced a significant ( p <0.001) increase in the latency in a dose-related manner. This study established the analgesic properties of Mimosa pudica Linn.
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Karthikeyan M, Deepa M K. Antinociceptive Activity of Mimosa pudica Linn. 3. 2010; 9 (1) :11-0
URL: http://ijpt.iums.ac.ir/article-1-201-en.html


Volume 9, Issue 1 (1-2010) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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