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:: Volume 7, Issue 2 (12-2008) ::
3 2008, 7(2): 161-0 Back to browse issues page
Neuropharmacological activity of the aqueous leaf extract of Croton zambesicus (euphorbiaceae) in some laboratory animals
Rashidat Oluwafunke Ayanniyi , Noel Nenman Wannang
Abstract:   (159 Views)
&nbsp;To determine the neuropharmacological activity of the leaf extract of Croton zambesicus in mice and chicks.&nbsp;The effect of aqueous leaf extract of Croton zambesicus on thiopental sodium &ndash; induced sleeping time in mice, on gross locomotor activity (GLA) in 2-day old chicks and effect of extract on apomorphine - induced stereotyped behavior in chicks were evaluated.&nbsp;The aqueous extract (1000 and 1500 mg/kg), administered per os (p.o), prolonged the thiopental sodium - induced sleeping time in mice. &nbsp; Extract (20-40 mg/kg i.p) produced a significant ( P < 0.05) decrease in GLA in 2-day old chicks in a dose dependent manner. 40-60 mg/kg administered intraperitoneally (i.p) produced sedation and sleep with a significant ( P < 0.05) decrease in onset and an increase in duration of sleep. The extract had an insignificant (P > 0.05) effect on apomorphine - induced stereotyped behavior in chicks.&nbsp; &nbsp; These results suggest that leaf extract of Croton zambesicus possesses CNS depressant, sedative, and hypnotic activity.
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Ayanniyi R O, Wannang N N. Neuropharmacological activity of the aqueous leaf extract of Croton zambesicus (euphorbiaceae) in some laboratory animals. 3. 2008; 7 (2) :161-0
URL: http://ijpt.iums.ac.ir/article-1-172-en.html
Volume 7, Issue 2 (12-2008) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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