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:: Volume 7, Number 1 (10-2008) ::
3 2008, 7(1): 83-0 Back to browse issues page
Protective Activity in Paracetamol Induced Hepatotoxicity and Antioxidant Potential from Lippia nodiflora (Verbenaceae) in Rats
Ashokkumar Durairaj, Thamil Selvan Vaiyapuri, Mazumder Upal Kanti, Gupta Malaya
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This study was designed to evaluate the hepatoprotective and antioxidant activity of methanol extract of Lippia nodiflora (MELN) in acute experimental liver injury induced by paracetamol (750mg/kg, b.w). MELN at the doses of 200 and 400mg/kg, p.o was administered for 7 days and biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin and total proteins with enzymatic and non-enzymatic antioxidant level were recorded. MELN at both doses prevented the increase in liver weight when compared to hepatotoxin treated control. The higher dose (400 mg/kg) of Lippia nodiflora extract was found to be more effective than the lower dose (200 mg/kg) in paracetamol induced liver damage. MELN produced significant ( p <0.001) hepatoprotective effect by decreasing the activity of serum enzymes such as SGOT, SGPT, ALP, bilirubin and lipid peroxidation while it significantly (p<0.001) increased the levels of total proteins, glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in a dose dependent manner. The activity of MELN was compared with standard drug silymarin (25mg/kg), which is a well-known natural anti-hepatotoxic drug and the potency of MELN is more or less the same at that of silymarin. &nbsp; It is concluded that the methanol extract of whole plant possesses good hepatoprotective activity probably by its antioxidative potential on hepatocytes.
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Article Type: Research Article |
Received: 2017/11/13
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Durairaj A, Vaiyapuri T S, Upal Kanti M, Malaya G. Protective Activity in Paracetamol Induced Hepatotoxicity and Antioxidant Potential from Lippia nodiflora (Verbenaceae) in Rats. 3. 2008; 7 (1) :83-0
URL: http://ijpt.iums.ac.ir/article-1-151-en.html
Volume 7, Number 1 (10-2008) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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