[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 6, Issue 2 (11-2007) ::
3 2007, 6(2): 171-0 Back to browse issues page
Effect of Honey on CYP3A4 Enzyme and P-Glycoprotein Activity in Healthy Human Volunteers
Vinod Thomas , Kesavan Ramasamy , Rajan Sundaram , Adithan Chandrasekaran
Abstract:   (1322 Views)
The activity of cytochrome p450 isozyme 3A4 (CYP3A4) enzyme and P-glycoprotein (P-gp) is modulated by grapefruit juice and herbal drugs. CYP3A4 is the major phase I drug metabolizing enzyme and P-gp is an ATP-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. Honey is commonly consumed as a dietary supplement. However, its influence on human CYP3A4 and P-gp activity is not yet well documented. Therefore, we investigated the influence of a 10-day honey administration on CYP3A4 and P-gp activity in healthy volunteers using carbamazepine and digoxin as their probe drugs respectively. A within-group pharmacokinetic study was done in 12 healthy volunteers. They were administered single oral dose of carbamazepine (200 mg) and digoxin (0.5 mg) before and after 10 days of honey (10 ml twice daily) intake. Blood samples (5ml) were collected at 0, 0.25, 0.5, 0.75, 1.0, 1.5, 2, 4, 8, 12, 24, 48 and 72 h after drug administration. Concentration of carbamazepine and digoxin in plasma was measured by HPLC and RIA method respectively. T en days of honey administration did not significantly alter the C max , T max and AUC (0-t) of carbamazepine (probe drug for CYP3A4) and digoxin (probe drug for P-gp). Our results suggest that honey may not significantly modulate the CYP3A4 enzyme and P-glycoprotein activity. The coadministration of honey with drugs may not result in significant drug interactions.
Full-Text [PDF 338 kb]   (503 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Thomas V, Ramasamy K, Sundaram R, Chandrasekaran A. Effect of Honey on CYP3A4 Enzyme and P-Glycoprotein Activity in Healthy Human Volunteers. 3 2007; 6 (2) :171-0
URL: http://ijpt.iums.ac.ir/article-1-134-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 6, Issue 2 (11-2007) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4642