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:: Volume 6, Issue 1 (9-2007) ::
3 2007, 6(1): 51-0 Back to browse issues page
Nimodipine Protects PC12 Cells against Oxygen-Glucose Deprivation
Nahid Rahbar Roshandel, Lili Razavi, Bahareh Tavakoli-Far
Abstract:   (254 Views)
The protective effect of a L-type calcium channel blocker, nimodipine, on cell injury induced by oxygen-glucose deprivation (OGD) in PC12 cells was investigated. PC12 cells were exposed to in-vitro oxygen-glucose deprivation (30 minutes and 60 minutes respectively) in the presence or absence of nimodipine (10mM/L) in three different time schedules (pre-24h, pre-3h and concurrently). Cellular viability was assessed by MTT assay. OGD-induced cell injury was significantly attenuated by nimodipine in all three treatment schedules. Application of MK801 (10mM/L), an antagonist of NMDA glutamate receptors also inhibited PC12 cell death by OGD method. Our study suggests that nimodipine has protective effects against OGD-induced neurotoxicity.
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Rahbar Roshandel N, Razavi L, Tavakoli-Far B. Nimodipine Protects PC12 Cells against Oxygen-Glucose Deprivation. 3. 2007; 6 (1) :51-0
URL: http://ijpt.iums.ac.ir/article-1-112-en.html

Volume 6, Issue 1 (9-2007) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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