4
Iranian Journal of Pharmacology and Therapeutics
9
14
1
2016
1
1
The effects of magnesium supplements on adi-ponectin level and insulin sensitivity in first-degree relatives of subjects with type 2 diabetes
1
6
EN
AREZOO
AFKHAMI-ARDEKANI
Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
BABAK
MAJIDI
Department of Internal Medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran
SAEEDEH
JAM ASHKEZARI
Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
MOHAMMAD HOSAIN
AFRAND
Ali-Ebne-Abitaleb Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran
SEID MOHAMMAD
MOHAMMADI
Department of Internal Medicine, Endocrinology, Shahid Sadoughi University of medical sciences, Yazd, Iran
MOHAMMAD
AFKHAMI-ARDEKANI
Department of Internal Medicine, Endocrinology, Shahid Sadoughi University of medical sciences, Yazd, Iran
The interaction between intracellular magnesium level, adiponectin production and insulin sensitivity has been recently suggested in both diabetic patients and their first-degree relatives. The present study aimed to investigate whether magnesium supplements are able to increase plasma adiponectin and af-fect insulin sensitivity in first-degree relatives of subjects with type 2 diabetes. Seventy subjects who were first-degree relatives of diabetic patients were randomly allocated to either Mg hydroxide supplementation plus lifestyle (case group, n= 35) or mere lifestyle change and placebo (control group, n= 35). The subjects were seen at 16-weeks intervals for at least 24 months. There was no difference in baseline level of adiponectin between intervention and control group (p= 0.612), but significantly increased in intervention group (mean change of 6.51 ± 4.33 mg/dl, p≤ 0.001) and significantly reduced in control group (0.70±0.52 mg/dl, p≤ 0.001) after 16-week intervention protocol. No difference was revealed in initial insulin resistance between the two study groups (p= 0.527), but it was revealed lower in intervention group after completing treatment (p≤ 0.001). On the other hand, after 16 week of initial interventions, insulin resistance index reduced as 0.56±0.85 units (p≤ 0.001), while increased in control group as 0.68 ± 0.78 units (p≤ 0.001). The increase in adiponectin production as well as decrease in insulin resistance is expected by administrating magnesium supplements in first-degree relatives of the patients with diabetes mellitus.
4
Iranian Journal of Pharmacology and Therapeutics
9
14
1
2016
1
1
Antiprotoscolices effect of methanolic extract of Zingiber officinale, Artemisia aucheri and Eucalyptus globulus against Echinococcus granulosus in vitro
7
11
FA
FARIBA
FAIZEI
Department of Parasitology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
AMIR HOSSEIN
MAGHSOOD
Department of Parasitology, School of Medicine Hamadan University of Medical Sciences & Health Services, Hamadan, Iran.
FATEMEH
PARANDIN
Department of Parasitology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
MOHAMMAD
MATINI
Department of Parasitology, School of Medicine Hamadan University of Medical Sciences & Health Services, Hamadan, Iran.
SHIRIN
MORADKHANI
Department of Pharmacognosy, Hamedan University of Medical Sciences, Hamedan, Iran.
MOHAMMAD
FALLAH
Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
First choice in the treatment of hydatid disease is still surgery. Leakage the live protoscolices during surgery and the risk of secondary cysts have been a permanent fair for surgeons. Various methods and materials have been used to kill protoscolices as well as drug therapy that most of them had serious side effects. The main objective of this study was to evaluate the in vitro scolicidal effect of methanolic extract of eucalyptus, artemisia and ginger. Protoscolices were collected aseptically from the hydatid cysts of the sheep; washed three times in sterile PBS and stored at 4 °C until use. Live protoscolices were exposed for 5, 10, 25, 40 and 60 min for three concentrations of the each extract (25, 50,100 mg/ml).The viability of the protoscolices were confirmed by 0.1% eosin staining method. The methanolic extract of ginger at concentration of 100 mg/ml, and eucalyptus at concentrations of 50, 100 mg/ml killed 100% of protoccolices after 40 min respectively. Scolicidal effect of all concentrations of the methanolic extract of ginger and eucalyptus was significant comparing to the control groups at all exposure times (P<0.001).No significant relationship was observed between the artemisia extract at different concentrations and exposure times comparing to the control groups (p=0.99). The results of this study showed that the eucalyptus and ginger
extract have high scolicidal activity and can be used as natural scolicidal agents.
4
Iranian Journal of Pharmacology and Therapeutics
9
14
1
2016
1
1
Dual role of CdSe quantum dots for simultaneous separation and spectrofluorimetric ultrasensitive determination of heparin
11
20
EN
BEHZAD
TORABI
Department of Analytical Chemistry, University College of Science, University of Tehran, Tehran, Iran.
FARZANEH
SHEMIRANI
Department of Analytical Chemistry, University College of Science, University of Tehran, Tehran, Iran.
ZAHRA
AHMADI JOOZDANI
Department of Analytical Chemistry, Science and Research branch, Islamic Azad University, Tehran, Iran.
FARZAD
TORABI
Department of Analytical Chemistry, University College of Science, University of Tehran, Tehran, Iran.
The present study offers a new method based on CdSe quantum dots (QDs) for simultaneous separation and determination of trace levels of heparin (Hep) in human serum samples. In this technique, CdSe QDs perform two different functions in Hep analysis process. Mercaptoacetic acid-capped red CdSe QDs
(λex=690 nm) are conjugated to Hep and the Hep-QD conjugation is then used as an extraction tool from microencapsulation of real samples. For quick release of the analyte from conjugation, the microcapsules are irradiated using an intensive near infrared wavelength as the controllable releasing agent. The Lcysteine-capped green CdSe QDs (λex=480 nm) play the additional role of Hep spectrofluorimetric detection. By labeling the appropriate chromophore, the extracted Hep can effectively quench green CdSe QD fluorescence which is quenched relative to Hep concentration. In comparison with other available methods, the newly-developed assay has a low detection limit (0.3 nmol L-1), wide linear range (1 to 8500 nmol L-1), good accuracy and high selectivity, that make it a good candidate for Hep separation and monitoring of complex physiological samples.
4
Iranian Journal of Pharmacology and Therapeutics
9
14
1
2016
1
1
Acute renal failure following brake fluid poisoning
21
23
EN
SEYED MOHAMMAD
NAVABI
Kermanshah University of Medical Sciences, Kermanshah, Iran.
JAFAR
NAVABI
HOSSEIN
POLADI
Legal Medicine Research Center, Kermanshan Province-General Office of Legal Medicine, Kermanshah, Iran
FERESHTA
ZAHERI
Legal Medicine Research Center, Kermanshan Province-General Office of Legal Medicine, Kermanshah, Iran.
Brake fluid is a mixture of different Glycol derivatives which are poisoning and their ingestion triggers significant CNS symptoms, severe metabolic acidosis, cardiac, pulmonary, and renal failure. Here in this study, a case is reported who had been ingested 150mL of brake fluid for suicidal attempt.