en پژوهشي Research Article The ethanol extract of the flowering top of Rosa damascena (Rosaceae) was assessed for neuropharmacological activities in mice using a number of experimental models. It significantly prolonged the pentobarbitone-induced sleeping time in mice, and showed mild to moderate central nervous system depressant activity when assessed by the hole cross and the open field tests in mice model when given at the doses of 250 and 500 mg/kg body weight. At the same dose levels, the extract dose-dependently inhibited acetic acid-induced writhing in mice. On the basis of these findings, it can be assumed that the extract exerts its depressant effect on the central nervous system in mice. 171 0 http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-95&slc_lang=en&sid=1 Mohammad Ashraful Alam 1003194753284600296 1003194753284600296 No Md. Abu bin Nyeem 1003194753284600297 1003194753284600297 No Md. Abdul Awal 1003194753284600298 1003194753284600298 No Mahbub Mostofa 1003194753284600299 1003194753284600299 No Nusrat Islam 1003194753284600300 1003194753284600300 No Sheikh Jamal Uddin 1003194753284600301 1003194753284600301 No