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1
3
Literature & Humanities
http://ijpt.iums.ac.ir
1
admin
9
10
8
7
14
8888
13
en
jalali
1385
6
1
gregorian
2006
9
1
5
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online
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fulltext
en
Beneficial Effects of Coenzyme Q10 in Streptozotocin-Induced Type I Diabetic Rats
پژوهشي
Research Article
The present investigation was undertaken to study the benefical effects of Coenzyme Q10 in streptozotocin (STZ)-induced type I diabetic rats. STZ-diabetes produced a significant increase in fasting glucose levels that was associated with decrease in serum insulin levels. STZ also produced hypercholesterolemia, hypertriglyceredemia, increase in lipid peroxidation and decrease in high density lipoprotein (HDL) levels. Treatment with Coenzyme Q10 produced a significant decrease in fasting glucose levels without affecting insulin levels. Coenzyme Q10 was also found to decrease significantly AUCglucose and no significant change in AUCinsulin values in STZ-diabetic rats. Treatment with Coenzyme Q10 also caused decrease in serum cholesterol, serum triglyceride levels and an increase in HDL levels. Coenzyme Q10 treatment also reduced lipid peroxidation in diabetic rats. The elevated blood pressure in diabetic rats was also lowered. Our data suggest that Coenzyme Q10 has beneficial effects in diabetes induced complications.
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http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-85&slc_lang=en&sid=1
Ketan P.
Modi
1003194753284600261
1003194753284600261
No
Santosh L.
Vishwakarma
1003194753284600262
1003194753284600262
No
Ramesh K.
Goyal
1003194753284600263
1003194753284600263
No
Parloop A.
Bhatt
1003194753284600264
1003194753284600264
No