en پژوهشي Research Article Sodium valproate has been widely used by man as an antiepileptic drug. Hair loss and curly hair is a rare side effect of sodium valproate. We have conducted a prospective clinical study in the Department of Neurology in Shafa Hospital, Kerman, Iran for ten years (1994-2004). All 211 epileptic patients in our study were given sodium valproate as a single drug treatment. During the course of therapy, all patients were strictly monitored every 3 months. Six cases (3.5% of valproate user population) of hair loss and curling of hair were found between sodium valproate users. Three cases were female and three were male. This side effect observed at least 3 months after its first initial drug therapy. The estimated frequency of curly hair along with hair loss in our study is lower than previously-reported frequencies (6-12%). 143 0 http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-64&slc_lang=en&sid=1 Hoseinali Ebrahimi 1003194753284600188 1003194753284600188 No Sadollah Shamsadini 1003194753284600189 1003194753284600189 No Shahriar Sadre Eshkavari 1003194753284600190 1003194753284600190 No