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Literature & Humanities
http://ijpt.iums.ac.ir
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admin
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10
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14
8888
13
en
jalali
1381
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1
gregorian
2002
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1
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online
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fulltext
en
Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats
پژوهشي
Research Article
Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP dependent potassium channel (KATP) modulators are thought to interfere with some physiologic functions of the stomach. We have studied the effects of different doses of KATP modulators (diazoxide as agonist and glibenclamide as antagonist) on EIGU in rats. Gastric lesions were quantified. Fasting blood glucose (FBS) levels were measured enzymatically. EIGU was prevented by diazoxide and aggravated by glibenclamide. Diazoxide increased and glibenclamide decreased FBS respectively. The present study shows that KATP modulators are involved in the production of EIGU with a mechanism which remains to be elucidated.
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http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-14&slc_lang=en&sid=1
Majid
Rahgozar
100319475328460014
100319475328460014
No
Hamid Reza
Pazoki Toroudi
100319475328460015
100319475328460015
No
Azam
Bakhtiarian
100319475328460016
100319475328460016
No
Bijan
Djahanguiri
100319475328460017
100319475328460017
No