en Inflammation and Immunopharmacology پژوهشي Research Article <div style="text-align: justify;"><em>Rosa canina </em>has been traditionally used in Iran as herbal medicine for treatment of painful and inflammatory conditions. The aim of this study is to evaluate the analgesic and anti-inflammatory activity of the aqueous extract of the <em>Rosa canina</em>in animal models of pain and inflammation. The analgesic effect was evaluated with hot plates a model of visceral pain in mice. Also inflammation produced by injection of formalin in paw of rats and the treatment by extract was assessed. Doses of extract used were 100, 300 and 700 mg/kg. The negative and positive control groups received normal saline and sodium salicylate respectively. The aqueous extract of <em>R. canina </em>could increase the latency time in mice in a dose-dependent manner (P<0.05). The pretreatment with extract significantly augmented the anti-nociceptive effects of <em>Rosa canina </em>and this was comparable with sodium salicylate and even more pronounced than sodium salicylate after 2 hours. Additionally, the inflammation induced by formalin was limited by aqueous extract of <em>R. canina </em>during acute and chronic phases of inflammation considered in 7 days period. The results of this study demonstrated the dose-dependent analgesic effects of <em>Rosa canina</em>aqueous extract in mice model of pain. And also our data showed dose-dependent anti-inflammatory action of the extract in formalin-induced edema. Our results contribute towards validation of the traditional use of <em>Rosa canina</em> in the management of pain and inflammatory conditions.</div> Rosa Canina, Aqueous extract, Inflammation, Nociception 1 6 http://ijpt.iums.ac.ir/browse.php?a_code=A-10-72-2&slc_lang=en&sid=1 SEYED MORTEZA TABATABAEE 10031947532846001435 10031947532846001435 No Department of pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran MOHAMMAD JAVAD YUSEFI 10031947532846001436 10031947532846001436 No Department of pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran MANIJEH MOTEVALIAN 10031947532846001437 10031947532846001437 Yes Department of pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran