en Other پژوهشي Research Article <div style="text-align: justify;"><em>Coriandrum sativum </em>has been used in Iranian traditional medicine as an anti-inflammatory, antioxidant, antibacterial, and antifungal agent. The purpose of this study was to evaluate the chemical composition and anti-parasitic property of essential oil of <em>C. sativum</em> leaf on trophozoite of <em>Trichomonas vaginalis</em>. <em>C. sativum</em> was collected from Kermanshah city and essential oil was prepared by the Clevenger device. The essential oil was analyzed by GC/MS. Trophozoite of <em>T. vaginalis</em> was cultured in vitro in CPLM medium and the effect of the essential oil on the survival of<em> T. vaginalis</em> trophozoite was measured by Neobar slide. This study indicated that Linalool (71.2%) was the most constituent found in <em>C. sativum</em> essential oil. Also, the results of anti-parasitic tests demonstrated the concentrations of 0.5, 0.25, 0.125, 0.062, 0.031, 0.015, 0.007, 0.003, and 0.001 g/ml in essential oil and 0.25 g/ml in metronidazole could destroy of<em> T. vaginalis</em> trophozoite completely after 420 minutes incubation. The best results were observed at 0.5 and 0.25 g/ml concentrations of essential oil, because these concentrations were able to destroy trophozoite in 90 minutes. Also, 0.001 g/ml concentration of essential oil had the lower anti-parasitic effect than all concentrations against <em>T. vaginalis</em> trophozoite. The trophozoite survived at DMSO after 600 minutes. MIC and MLC of <em>C. sativum essential oil</em> were 0.015 and 0.031 g/ml concentrations, respectively. In our study, the essential oil of <em>C. sativum</em> leaf in several concentrations destroyed <em>T. vaginalis</em> trophozoite<em>. </em>It appears that <em>C. sativum</em> can be used for the treatment of some <em>T. vaginalis </em>infections as an antibiotic.<br> &nbsp;</div> Coriandrum sativum, Essential oil, Chemical characterization, Anti-parasitic property, Trichomonas vaginalis 1 7 http://ijpt.iums.ac.ir/browse.php?a_code=A-10-120-1&slc_lang=en&sid=1 ABDOLALI CHALECHALE abdolalichalechale@yahoo.com 10031947532846001969 10031947532846001969 No Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran. MOHAMMAD MAHDI ZANGENEH m.mahdizangeneh@gmail.com 10031947532846001970 10031947532846001970 Yes Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran. AKRAM ZANGENEH akramzangeneh@yahoo.com 10031947532846001971 10031947532846001971 No Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran. YAZDAN HAMZAVI yamzavi@gmail.com 10031947532846001972 10031947532846001972 No Department of Parasitology and Mycology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. ZARRINTAJ VALADKHANI valadzarrin@gmail.com 10031947532846001973 10031947532846001973 No Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran.