en Endocrine and Reproductive پژوهشي Research Article <style type="text/css">p.p1 {margin: 0.0px 0.0px 10.0px 0.0px; font: 10.0px 'Times New Roman'; color: #000000; -webkit-text-stroke: #000000} span.s1 {font-kerning: none} </style> <div class="p1" style="text-align: justify;"><span style="font-size:14px;"><span class="s1">Presently drugs that are available to treat the diabetic induced cognitive impairment presents adverse effect on long term used. This study offers evidence that old drugs can be combined and used. Existing and affordable drugs can be repurposed and can benefit patients .The study used a combination of drugs with proven safety for preventing/delaying the development of cognitive impa</span></span><span style="font-size:14px;"><span class="s1">irment in diabetes with a hope to improve the quality of life of diabetic patients.In current&nbsp; study diabetic rats were treated for eight weeks&nbsp; with combination of gamma linolenic acid (30mg/kg,p.o), alpha lipoic acid (30mg/kg,p.o), phloroglucinol (250mg/kg,p.o) l-thyroxine (1mg/kg, s.c) in one group and combination of&nbsp; of gamma linolenic acid (30mg/kg,p.o), alpha lipoic acid (30mg/kg,p.o), allantoin (200mg/kg,p.o), l-thyroxine (1mg/kg,s.c) in other group.The degree of preventative was determined by various parameters like body weight, measurement of neurotransmitter and calculating glycosylated haemoglobin and behavioural studies to check whether combination therapy has positive impact on diabetic induced cognitive impairment.</span></span></div> <p class="p1" style="text-align: justify; margin-left: 80px;"><span style="font-size:12px;"><span class="s1">.</span></span></p> Keywords- Gamma linolenic acid, Alpha lipoic acid, Phloroglucino, Allantoin, l-thyroxine 1 6 http://ijpt.iums.ac.ir/browse.php?a_code=A-10-95-1&slc_lang=en&sid=1 TENZIN TENDER tentenderla007@gmail.com 10031947532846001964 10031947532846001964 Yes Al-Ameen College of Pharmacy, Rajiv Gandhi University of health Science, Bangalore, India SR MUBEENA moinmubeena45@gmail.com 10031947532846001965 10031947532846001965 No Al-Ameen College of Pharmacy, Rajiv Gandhi University of health Science, Bangalore, India