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Literature & Humanities
http://ijpt.iums.ac.ir
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admin
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10
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14
8888
13
en
jalali
1396
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gregorian
2017
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15
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online
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fulltext
en
Β- Glucan, a Polysaccharide Found in Avena sativa (Oat), Attenuated Chronic Unpredictable Mild Stress Induced Cognitive Impairment in Rodents via Normalizing Corticosterone Levels
Neuropharmacology
Short Communication
The current study was aimed at exploring the effect of β-glucan (a naturally occurring polysaccharide) on chronic unpredictable mild stress (CUMS) induced impairment in learning and memory. Briefly, the animal model of CUMS was generated (28 days) followed by assessment of the efficacy of β-glucan (2.5, 5 or 10 mg/kg) on learning and memory in Morris water maze (MWM). Moreover, the weight variation during the course of experiment and post-MWM corticosterone levels was also noted. Our data showed that the β-glucan provided dose dependent protection against deleterious effects of stress on spatial memory, which became statistically significant at 10 mg/kg. In similar manner, it has also antagonized the stress induced weight loss and corticosterone elevation. Taking everything into account, it can be deduced that β-glucan possesses therapeutic potential against stress induced cognitive impairment and this effect can be attributed to its normalizing effect on corticosterone levels.
β-glucan, Chronic unpredictable mild Stress, Corticosterone, Morris water maze, Spatial Memory
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http://ijpt.iums.ac.ir/browse.php?a_code=A-10-36-1&slc_lang=en&sid=1
SANIYA
HASHIM
saniya.hashimkhan@gmail.com
10031947532846002121
10031947532846002121
No
Pharmacy Department, COMSATS Institute of Information Technology, Abbottabad, KPK, Pakistan
ALI
HAIDER
alihaider.rph@gmail.com
10031947532846002122
10031947532846002122
No
Pharmacy Department, COMSATS Institute of Information Technology, Abbottabad, KPK, Pakistan
SHERAZ
KHAN
sheraz.sherrykhan@gmail.com
10031947532846002123
10031947532846002123
No
Pharmacy Department, COMSATS Institute of Information Technology, Abbottabad, KPK, Pakistan
GHULAM
ABBAS
dr.ghulamabbas@yahoo.com
10031947532846002124
10031947532846002124
Yes
Pharmacology Section, H.E.J. Research Institute of Chemistry, International Centre for Chemical & Biological Sciences, University of Karachi, Karachi