en پژوهشي Research Article The present study was aimed to evaluate the beneficial effect of Cystone syrup in an experimental model of glycerol-induced acute renal failure (ARF) in rats. Biochemical parameters, kidney weight and histopathological evaluation were performed to conclude the beneficial effect of Cystone syrup. Administration of single dose of 50% v/v glycerol (8ml/kg.i.m) caused severe renal dysfunction associated with significant increase in markers of renal function such as serum urea ( p <0.01), creatinine ( p <0.01), blood urea nitrogen (BUN) ( p <0.01), decrease in the Creatinine clearance (Ccr) ( p <0.01) and increase in kidney weight to body weight ratio ( p <0.01) compared to control group. These changes were in accordance with the histopathological findings showing severe tubular necrosis, degeneration and moderate luminal cast formation. In contrast, pre-treatment with Cystone (5 ml/kg, p .o) for seven days, alleviated the glycerol induced renal dysfunction significantly by maintaining serum urea ( p <0.01), creatinine ( p <0.05), BUN ( p <0.01) and kidney weight to body weight ratio ( p <0.05) near to normal range, also improved the creatinine clearance ( p <0.05) compared to untreated positive control. In addition, histopathology of Cystone (5 ml/kg, p.o) treated group showed mild to moderate tubular necrosis and degeneration. Thus, the findings of the present study demonstrates the usefulness of Cystone syrup in reversing the biochemical/ structural markers of renal dysfunction observed in experimental model of renal failure in rats. 40 0 http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-258&slc_lang=en&sid=1 M. Rafiq 1003194753284600872 1003194753284600872 No G. L. Viswanatha 1003194753284600873 1003194753284600873 No M. Mohammed Azeemuddin 1003194753284600874 1003194753284600874 No D. A. Suryakanth 1003194753284600875 1003194753284600875 No V. K. Uday Kumar 1003194753284600876 1003194753284600876 No P. S. Patki 1003194753284600877 1003194753284600877 No