en پژوهشي Research Article A hydroethanolic extract (HE-ext) of Bacopa monnieri (BM) was studied for antinociceptive effect in the animal models of acetic-acid-induced writhing test and antilocomotive effect in mice. Standard centrally-acting analgesic, morphine (MP), and peripherally-acting one, diclofenac (Diclo), were also tested along with the extract for comparison. The extract exhibited significant antinociceptive effect ( p < 0.001) in this test, not antagonized by the opioid receptor antagonist, naloxone (NLX) in a fashion similar to diclofenac. This excluded the involvement of opioids in the mediation of antinociceptive response of Bacopa monnieri . Moreover, the BM HE-ext exhibited highly significant antilocomotive ( p < 0.0001) that was also unaffected by naloxone. These results indicate that Bacopa monnieri possesses antinociceptive and antilocomotive effect that may be mediated through non-opioidergic mechanism. 15 0 http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-247&slc_lang=en&sid=1 Muzaffar Abbas 1003194753284600831 1003194753284600831 No Fazal Subhan 1003194753284600832 1003194753284600832 No Khalid Rauf 1003194753284600833 1003194753284600833 No Ikram ul-Haq 1003194753284600834 1003194753284600834 No Syed Nadeem-ul-Hassan Mohani 1003194753284600835 1003194753284600835 No