2
1
3
Literature & Humanities
http://ijpt.iums.ac.ir
1
admin
9
10
8
7
14
8888
13
en
jalali
1391
7
1
gregorian
2012
10
1
11
1
online
1
fulltext
en
Pharmacology and Toxicology of Leflunomide
پژوهشي
Research Article
Leflunomide (LEF), used for rheumatoid arthritis, inhibits dihydro-orotate dehydrogenase (DHODH) and tyrosine kinase (TK) enzymes and has anti-inflammatory, lymphocyte proliferation regulatory, immunosuppression and chondroprotective effects. The most common adverse effects are gastrointestinal disorders, weight loss, hypertension, skin infection, and neurological and hematological toxicity. It also produces hepatotoxicity and teratogenic effects on long term therapy. The Food and Drug Administration (FDA) categorized it as black box warning drug since 2010. Therefore, it is necessary to give toxicological informations to scientific communities. This review article is elaborately describes the toxicity of this drug during its long and short term therapies.
26
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-245&slc_lang=en&sid=1
Ram Lal
Lodhi
1003194753284600825
1003194753284600825
No
Shubhini A.
Saraf
1003194753284600826
1003194753284600826
No
Gaurav
Kaithwas
1003194753284600827
1003194753284600827
No
Assistant Professor, Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Rai Barely Road, Lucknow 226025, Lucknow
Sudipta
Saha
1003194753284600828
1003194753284600828
No