en پژوهشي Research Article This study was designed to evaluate the hepatoprotective and antioxidant activity of methanol extract of Lippia nodiflora (MELN) in acute experimental liver injury induced by paracetamol (750mg/kg, b.w). MELN at the doses of 200 and 400mg/kg, p.o was administered for 7 days and biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin and total proteins with enzymatic and non-enzymatic antioxidant level were recorded. MELN at both doses prevented the increase in liver weight when compared to hepatotoxin treated control. The higher dose (400 mg/kg) of Lippia nodiflora extract was found to be more effective than the lower dose (200 mg/kg) in paracetamol induced liver damage. MELN produced significant ( p <0.001) hepatoprotective effect by decreasing the activity of serum enzymes such as SGOT, SGPT, ALP, bilirubin and lipid peroxidation while it significantly (p<0.001) increased the levels of total proteins, glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in a dose dependent manner. The activity of MELN was compared with standard drug silymarin (25mg/kg), which is a well-known natural anti-hepatotoxic drug and the potency of MELN is more or less the same at that of silymarin. &nbsp; It is concluded that the methanol extract of whole plant possesses good hepatoprotective activity probably by its antioxidative potential on hepatocytes. 83 0 http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-161&slc_lang=en&sid=1 Ashokkumar Durairaj 1003194753284600522 1003194753284600522 No Thamil Selvan Vaiyapuri 1003194753284600523 1003194753284600523 No Mazumder Upal Kanti 1003194753284600524 1003194753284600524 No Gupta Malaya 1003194753284600525 1003194753284600525 No