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Showing 4 results for Sridhar
Vrushabendra Swamy, Sridhar Chandanam, Sreenivasa Rao, R Dhanapal, V Balamuralidhar, Ashoka Babu,
Volume 4, Issue 1 (6-2005)
Abstract
The methanolic extract of fruit of Benincasa hispida (BHFE) was evaluated for its antidiarrheal potential against several experimental models of diarrhea in rats. BHFE treated animals showed significant inhibi-tory activity against castor oil induced diarrhea and inhibited PGE2 induced enter pooling in rats. It also showed significant reduction in gastro intestinal motility following charcoal meal in rats. The result ob-tained and establishes the efficacy of BHFE as an antidiarrheal agent.
Peddyreddy Murali Krishna Reddy, Vinod Thomas, Govindarajan Nartunai, Chenchugari Sridhar,
Volume 4, Issue 2 (11-2005)
Abstract
Vijaykumar Pandurang Rasal, Arulmozhi Sinnathambi, Purnima Ashok, Sridhar Yeshmaina,
Volume 7, Issue 1 (10-2008)
Abstract
Morinda citrifolia (Noni) has been traditionally used for bone and wound healing. The present study was carried out to investigate the effect of Morinda citrifolia leaves on experimental wounds and lipid peroxide levels in rats. Effect of aqueous extract of leaves of Morinda citrifolia (200 mg/kg) on excision, resutured incision and dead space wound models were studied. Measurement of blood malondialdehyde (MDA) levels and histopathological studies were also carried out. There was a significant increase (p<0.0001) in wound contraction rate, tensile strength, granuloma breaking strength, collagen content, dry granuloma weight (p<0.01) and hydroxyproline content. A significant decrease (p<0.0001) in epithelialisation period and MDA levels in Morinda citrifolia leaf extract treated group were observed when compared to control group. From the results, it may be concluded that the M. citrifolia aqueous leaves enhances the wound healing and possess antioxidant activity.
Ravindrababu Pingili, Sridhar Vemulapalli, Surya Sandeep Mullapudi, Sivaramakrishna Kondru, Naveen Babu Kilaru,
Volume 14, Issue 2 (8-2016)
Abstract
Since long back, herbal medicines have been the highly-esteemed source of medicine; therefore, they have become a growing part of modern, high-tech medicine. Zephyranthes candida (ZC) has been mentioned in the Indian System of Traditional Medicine for the treatment of diabetes mellitus. The objective of this study was to evaluate the anti-diabetic activity of methanolic leaf extract of Zephyranthes candida (MLZ) and its different fractions in healthy and Streptozotocin (STZ)-induced diabetic rats. Healthy wistar and STZ-induced diabetic rats were treated orally with MLZ (100, 200 and 400 mg/kg) and glipizide (5 mg/kg) for 21 consecutive days. Blood samples were collected from the retro orbital plexus on 1 st , 8 th , 15 th and 21 st day. In another study, STZ-induced diabetic rats were treated with glipizide (5 mg/kg), fraction I [hexane: ethyl acetate (1:1)], fraction II [chloroform: methanol (1:1)] and fraction III [chloroform: methanol (2:8)]. Blood glucose levels and lipid profiles were determined using ERBA, semiautoanalyzer. The methanolic extract was further analyzed for phytochemical analysis. MLZ (100, 200 and 400 mg/kg) showed a signi?cant reduction in blood glucose levels which were comparable to that of the standard anti-diabetic drug, glipizide. The total cholesterol, triglycerides and low density lipoproteins levels were significantly reduced by MLZ in diabetic rats. All the three fractions are also reduced the blood glucose levels after single oral administration ( p<0.01 ). In phytochemical analysis, MLZ showed the presence of flavonoids, glycosides and alkaloids. The present study results indicated that Zephyranthes Candida possess anti-diabetic and lipid lowering effects may be due to the antioxidant activity of flavonoids or alkaloids. Further studies are needed to elucidate the structures and to evaluate the exact mechanism of anti-diabetic action of the active components.
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