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Showing 6 results for RAHMAN
Ranajit Kumar Sutradhar, Akm Matior Rahman, Mesbahuddin Ahmad, Sitesh Chandra Bachar, Achinto Saha, Samar Kumar Guha,
Volume 5, Issue 2 (12-2006)
Abstract
In the present study, the analgesic and anti-inflammatory activities of a new alkaloid (5′-Hydroxymethyl-1′-(1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin-1-yl)-heptan-1-one) (compound 1), isolated from Sida cordifolia Linn. was investigated in animal models. The analgesic activity was investigated in the acetic acid induced writhing and the radiant heat tail flick model in mice and the carrageenan induced rat paw edema model was used for anti-inflammatory study. The compound produced significant ( p <0.01) analgesic activity in both models. The compound also exhibited significant ( p <0.01) inhibition of rat paw edema induced by carrageenan. These results indicated that compound 1 possessed analgesic and anti-inflammatory activities .
Farhad Heshmati, Heidar Noroozinia, Rahman Abbasivash, Helen Gharaee,
Volume 5, Issue 2 (12-2006)
Abstract
Introduction: The most important role in postoperative pain management is still played by opioids administered through various modes. In the last few years, there had been an intensive search for alternative mode of opioids administration in pain management. The intranasal mode of opioids administration seems to be attractive alternative.
Methods: Sixty boys (aged 0.5-6 yr); ASA physical status I, II were included in this prospective randomized controlled study. Five minutes before awake extubation, patients were allocated to receive intranasal sufentanil (0.7 µg/kg) or normal saline, using a double-blinded study design.
Results: Satisfactory analgesia was achieved with sufentanil (p = 0.001) and it was effective during time, after 10 minutes with the least pain scores. Pain scores in 15, 20 and 25 minutes were similar in sufentanil group. None of patients had bradycardia, hypotension or SpO2 <95%.
Conclusion: High bioavailability of sufentanil after intranasal administration due to direct entrance of the drug into the systemic circulation and avoidance of the hepatic first- pass effect makes sufentanil as an opioid with rapid onset and limited duration. As its minimal side effects, sufentanil is one of the best choices for postoperative pain control in children. We used 0.7 µg/kg of sufentanil and found satisfactory analgesia accompanying with least side effects.
Loubna Farouk, Amine Laroubi, Abderrahim Ouachrif, Rachida Aboufatima, Ahmed Benharref, Abderrahman Chait,
Volume 8, Issue 1 (5-2009)
Abstract
The seeds of Peganum harmala L. ( Pgh ) (Zygophyllaceae) have been used in Moroccan traditional medicine for treatment of a various diseases and to relieve dolorous process. The major objective of this paper was to investigate the analgesic effect of ethyl acetate (EAE), butanolic (BE) and aqueous (AqE) extracts of seeds of Peganum harmala and elucided the possible underlying action mechanism of each extract. In the present work, the antinociceptive action was assayed in several experimental models in mice: writhing, formalin, tail flick and hot plate tests. The EAE, BE and AqE given by i.p or p.o. routes showed significant reduction in acetic acid induced writhings in mice with a maximum effect of 35.12 % reduction of BE at dose 25 mg/kg, i.p. (p<0.001). In the formalin test, the pre-traetment with EAE and BE (12.5 and 25mg/kg, i.p.) caused marked and dose-related inhibition of formalin-induced licking in mice in the both phase, whereas, the AqE (25mg/kg, i.p.) reduced the nociception response only in the second phase of formalin test. The results on hot plate and tail flick tests, showed a significant central acting analgesic properties of EAE and BE. These result showed that the EAE and BE, which were the most effectives, contains active analgesic principles acting both centrally and peripherally. Preliminary phytochemical screening of the extracts showed the presence of alkaloids, flavonoids, quinons and saponin. Furthermore, this antinociceptive effect has been avoided by naloxone at a dose 1 mg/kg in the first phase of formalin and hot plate tests indicating that these extracts acts partly through an opioid-mediated mechanism. In conclusion, our results demonstrated that the different extracts of Peganum harmala had both central and peripheral antinociceptive activities that may be mediated by opioid receptors.
Alam Khan, Ekramul Haque, Bytul M Rahman, Matiur Rahman,
Volume 8, Issue 1 (5-2009)
Abstract
The neuropharmacological effect of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the rhizome of Drynaria quercifolia J. Smith were studied in mice by intraperitoneal administration. The tests used were determination of effect on duration of diazepam-induced sleep, determination of effect on nikethamide-induced toxicity, light-dark test and force swimming test. The duration of diazepam-induced sleep was extended by administration of these fractions. Nikethamide at high dose cause death of mice and time to cause death of mice was delayed by administration of these fractions. In light-dark test and force swimming test these fractions were given diazepam type effect. The changes in doses (50-200 mg/kg) showed changes in efficiency of these effects. These results suggest that both these fractions of D. quercifolia rhizome have dose dependent depressant effect.
Ghasem Mohammadpour, Rahmat Tahmasbpour, Alireza Rahmani, Aliakbar Ali Esfahani,
Volume 16, Issue 1 (6-2018)
Abstract
Trachyspermum copticum is one of the most important Iranian Apiaceae species which is widely distributed in the northern region of Iran. In this study, chemical compounds, anti-tumor and antibacterial activities of T. copticum essential oil were evaluated. The essential oil obtained by Clevenger apparatus and then the chemical composition was analyzed by GC-MS. Antibacterial activity of essential oil was evaluated by well diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by the macrodilution method. An MTT cytotoxicity assay was employed to test effects of the essential oil on each human breast cancer cell lines. The GC-MS spectrums showed 9 major compounds, in which the highest chemical composition was related to thymol (42.16%), g-Terpinene (31.49%) and p-cymen (23.29%) compounds. T. copticum essential oil showed good antitumor activity on SKOV3 and MDA-MB-231cell lines (IC50 of 208.13.6µg/ml and IC50 236.16µg/ml, respectively). It also showed good activity against to tested bacteria. The MIC and MBC values of the bacterial strains sensitive to the essential oil were in the ranges of 0.4 to 3.1 mg/ml and 0.4 to 6.25 mg/ml, respectively. Because of the high concentration of phenolic compounds, the essential oil from T. copticum exhibited antimicrobial and antitumor activities, which deserve further research into the chemoprevention and treatment of human ovary and breast cancers as well as infectious diseases.
Farzad Rahmani, Parvaneh Najafizadeh, Zahra Mousavi, Tayebeh Rastegar, Elmira Barzegar,
Volume 16, Issue 1 (6-2018)
Abstract
Quercetin is one of the major flavonoids finding in many fruits and vegetables. Quercetin has many health promoting advantages such as improvement of allergic, arthritis disorder, and reduction of cancer and cardiovascular risk. The aim of this study was to examine hepatoprotective effects of quercetin on doxorubicin induced toxicity in animal model. Thirty male Wistar rats (200-230 g) were randomly divided in to 5 groups including: Quercetin group was orally treated with 20 mg/kg of quercetin for 14 days. Doxorubicin group was treated with 25 mg/kg of doxorubicin i.p. for 3 days. Doxorubicin- Quercetin group (DQ) was orally pre-treated of 20 mg/kg quercetin for 14 days with hepatotoxicity induced by i.p. injection of 25 mg/kg doxorubicin (12th, 13th and 14th days). The control and vehicle group were orally received saline (1 mL/kg), and DMSO (1 mL/kg) respectively. Sample of their livers were used to determine the myeloperoxidase (MPO) activity, superoxide dismutase (SOD), malondialdehyde (MDA), GPX, catalase, and histological analysis. The numerical data were evaluated by ANOVA, followed by the Tukey tests. The results show that doxorubicin could produce hepatotoxicity in rat. Also, increased liver enzymatic (ALT, AST, ALP), MPO, MDA (p<0.001), followed infiltration of inflammatory cell, and necrosis of hepatocytes also Pretreatment with quercetin reduces MPO activity (p=0.0034), MDA (p=0.0335) and the elevated liver ALT (0.009), ALP (p=0.0023) and AST activity (0.0074) in rats in DQ group. This study suggests that quercetin have a protective effect on the liver tissue against toxicity induced by doxorubicin.
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