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Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} The stem bark of Oroxylum indicum ( Fam. Bignoniaceae) was extracted with methanol. The methanol extract was fractionated with pet ether, chloroform, hexane and carbon tetrachloride using modified Kupchan partitioning method. Extensive chromatographic separation and purification with the organic solvent was done. One compound was extracted from the n-hexane fraction of stem bark of O. indicum which was then confirmed as flavonoid type of compound by using 1 H NMR spectrometric analysis. Three fractions (hexane, carbon tetrachloride, chloroform), obtained from methanolic crude extract, were tested for antimicrobial activity by standard disc diffusion method. The extracts were found to show antimicrobial activities towards the gram-positive and gram-negative bacteria, and some fungi . The results were compared with same microbial strains against a standard antibiotic disc of ampicillin (10 m g/disc).

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The   stembark of Mammea africana is used traditionally for the treatment of stomach pains. The present study was designed to evaluate the effects of ethanolic stembark extract of Mammea africana on experimentally induced diarrhoea and ulcer . The extract ( 30 – 90mg/kg) was administered orally in rats 30 minutes to one hour before the induction of diarrhoeal and ulcer using different experimental models. Castor oil (2ml) was used to induce diarrhoea, while indomethacin (60mg/kg) and ethanol (2.5ml/kg) were used to induce ulcers in rats. F requency of defecation , inhibition of intestinal propulsion and fluid accumulation were measured in the case of diarrhoea and ulcer index were calculated to examine ulcer preventive ratio of the extract. The extract ( 3 0 – 9 0mg/kg) significantly   inhibited   castor oil induced diarrhoea, small intestine transit time and castor oil induced fluid accumulation as well as indomethacin and ethanol induced ulcer models. The effect of the extract in th ese models was un comparable to the various standard drugs used. These findings justify the use of this stembark traditionally in the treatment of stomach pains and disorders.

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In the present investigation, methanolic extract of Mimusops elengi  leaves were evaluated for wound healing activity. Entire wound healing process is complex series of events that begins at the moment of injury and can continue for months to years. Methanolic extract of Mimusops elengi leaves were examined for wound healing activity in the form of ointment by the excision, the incision and dead space wound model in mice. The extract ointments showed considerable wound healing properties with excision wound model ( p <0.001), incision wound model ( p <0.05), and dead space wound model ( p <0.05) when results were compared with control. Standard used for the present study was Betadine ointment in terms of wound contracting ability, wound closure time, tensile strength and dry granuloma weight. Results obtained clearly indicated that methanolic extract of Mimusops elengi  leaves exhibit significant wound healing properties.