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Showing 4 results for AHMADI
A. Ahmadi, J. Solati, M. Khalili,
Volume 9, Issue 2 (9-2010)
Abstract
Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Phencyclidine (1-(1-phenylcyclohexyl) piperidine, CAS 956-90-1, PCP, I) and its derivatives have shown many pharmacological and behavioral effects. Also, food and water intake of many drugs such as PCP and its analogues have been studied in laboratory animals. In this work, two derivatives (II, III) of phencyclidine were tested for feeding behaviors effects on rats and compared to PCP and vehicle (saline) . The results showed that, both derivatives can increase food and water intake in comparison to the PCP and vehicle (control) groups that have measured 1-12 h for food and 30–180 min for water intake after injection.
Behzad Torabi, Farzaneh Shemirani, Zahra Ahmadi Joozdani, Farzad Torabi,
Volume 14, Issue 1 (1-2016)
Abstract
The present study offers a new method based on CdSe quantum dots (QDs) for simultaneous separation and determination of trace levels of heparin (Hep) in human serum samples. In this technique, CdSe QDs perform two different functions in Hep analysis process. Mercaptoacetic acid-capped red CdSe QDs
(λex=690 nm) are conjugated to Hep and the Hep-QD conjugation is then used as an extraction tool from microencapsulation of real samples. For quick release of the analyte from conjugation, the microcapsules are irradiated using an intensive near infrared wavelength as the controllable releasing agent. The Lcysteine-capped green CdSe QDs (λex=480 nm) play the additional role of Hep spectrofluorimetric detection. By labeling the appropriate chromophore, the extracted Hep can effectively quench green CdSe QD fluorescence which is quenched relative to Hep concentration. In comparison with other available methods, the newly-developed assay has a low detection limit (0.3 nmol L-1), wide linear range (1 to 8500 nmol L-1), good accuracy and high selectivity, that make it a good candidate for Hep separation and monitoring of complex physiological samples.
Maziar Ganji, Hosam-Eldin Hussein Osman, Jamshid Karimi, Seyed Abdolhakim Hosseini, Heresh Moridi, Asieh Hosseini, Davoud Ahmadimoghaddam, Akram Ranjbar,
Volume 15, Issue 1 (6-2017)
Abstract
Regardless of toxicity of nanoparticles, cerium oxide nanoparticles (CeNPs) are emerging as a multi-functional agent for biomedical purposes. On the other hand, Organophosphorus pesticides, like malathion, are inevitably found in the environment. The common involving pathway CeNPs and malathion share is oxidative stress. Therefore, we conducted this study to find the possible neutralizing or synergistic effects of CeNPs on oxidative stress responses in malathion-induced toxicity by intraperitoneal (IP) injection. In this experimental study, 40 Wistar male rats with the weight range of 200-250 g were randomly selected and divided into eight groups. Group1 (control, normal saline), group2 (100 mg/kg/day malathion /IP), group3 (15 mg/kg/day CeNPs/IP), group4 (30 mg/kg/day CeNPs /IP), group5 (60 mg/kg/day CeNPs /IP), group6 (100 mg/kg/day malathion+15 mg/kg/day CeNPs /IP), group7 (100 mg/kg/day malathion+30 mg/kg/day CeNPs /IP) and group8 (100mg/kg/day malathion+60 mg/kg/day CeNPs /IP). After 4 weeks of treatment, the levels of lipid peroxidation (LPO), total antioxidant capacity (TAC), total thiol molecules (TTM) and activity of catalase (CAT) in lung tissue were measured. All data were analyzed by SPSS V16 and One way ANOVA with Tukey post hoc test. The results demonstrated that CeNPs caused significant increases in LPO and TAC, in a dose-dependent-manner. For TTM level, none of the groups presented any significant change compared to control. Significantly decreased levels of CAT, also, were seen in all treatment groups. Surprisingly, all animals of group 8 died. Worth of noting, groups receiving combined CeNPs and malathion showed severe responses for these parameters. These results discovered that CeNPs induces oxidative stress parameters and ROS production, especially combined with malathion in lung tissue. Groups receiving both CeNPs and malathion displayed synergistic toxic properties. LPO, TAC and CAT seem to be better parameters for measuring CeNPs-induced responses. Further investigations are required to shed light on clear mechanisms involved.
Mehdi Torabi, Somayyeh Karami-Mohajeri, Rasool Mirzali, Fatemeh Nematipour, Jafar Ahmadi, Milad Ahmadi,
Volume 15, Issue 1 (6-2017)
Abstract
Aluminum phosphide (ALP) poisoning has a high mortality rate. The purpose of this study was to evaluate the efficacy of lipid emulsion (ILE) and N-acetyl cysteine (NAC) in the treatment of aluminum poisoning in the rat model. This experimental study was conducted on thirty-three rats. Six rats in the control group were given oral corn oil and twenty-seven rats in the other groups were orally poisoned using ALP dissolved in corn oil (Control group, ALP group, ALP-NAC group, ALP-ILE group). All the rats were monitored for hemodynamics and ECG parameters. Mixed ANOVA analysis was applied to compare means across groups. Actuarial life table analysis was applied to compare the survival rate of rats. In terms of hemodynamics, ALP group had a significant difference in means of heart rate (HR) and shock index (SI) compared to the control group (P = 0.04; P = 0.00, respectively). The ALP-ILE group had no significant difference in means SBP, HR and SI compared to control group (p=1.00, p= 0.58, p=1.00, respectively). In ALP-NAC group, there was a significant difference in means HR and SI compared to the control group (p=0.01, p= 0.00, respectively). The ALP-NAC group had no significant differences in means of SBP, HR ,and SI compared to ALP group but the ALP-ILE group had significant differences in means of SBP and SI. Considering ECG in ALP, ALP-NAC and ALP-ILE groups, changes in the PR interval and duration of QT were not significant compared to the control group. In the ALP-NAC and ALP-ILE groups had no significant differences in means of QT and PR interval compared to the ALP group.There was a 45% survival rate in the ALP-ILE group at the end of 3rd day. Lipid peroxidation in the ALP and ALP-ILE groups significantly increased in comparison to the control group. The total antioxidant capacity (TAC) in the ALP-ILE group increased significantly compared to the control group but was significantly lower than those treated with NAC. In this study, two therapeutic strategies were compared in the treatment of ALP-poisoning. NAC with antioxidant properties and ILE with lipophilicity property. ILE due to its different osmolarity with intravascular osmolarity improves hemodynamic changes and compensates for the systemic effects of aluminum phosphide.
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