[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 4, Issue 2 (11-2005) ::
3 2005, 4(2): 84-0 Back to browse issues page
Enhanced Therapeutic Benefit of QuercetinPhospholipid Complex in Carbon Tetrachloride-Induced Acute Liver Injury in Rats: A Comparative Study
Kuntal Maiti , Kakali Mukherjee , Arunava Gantait , Haja Nazeer Ahamed , Bishnu Pada Saha , Pulok Kumar Mukherjee
Abstract:   (1969 Views)
Quercetin is a typical flavonoid with diverse biological effects, attributable to its free radical scavenging activity. Bioavailability of quercetin aglycone and its glycosides is an important factor for its antioxidant activity in vivo. A severe limitation exists and is imputable to very poor absorption of quercetin when administered orally. To overcome this limitation, development of a value added herbal formulation in combination with phospholipids has been made which has better absorption and utilization profiles. Free radical scavenging activity of quercetinphospholipid complex (equivalent to quercetin 10mg and 20 mg/kg body wt.) and free quercetin (10 mg and 20 mg/kg body wt.) was evaluated in oxidative stress condition in albino rats induced by carbon tetrachloride intoxication. The degree of protection of liver was estimated by evaluating status of enzymes like super oxide dismutase (SOD), catalase; lipid peroxidation profile in terms of thiobarbituric acid reactive substances (TBARS), reduced glutathione, glutathione peroxidase, glutathione reductase and glutathioneStransferase. Quercetinphospholipid complex restored the reduced enzyme levels of liver glutathione system as well as impaired levels of other enzymes which are significant with respect to carbon tetrachloride treated group (p < 0.05 and < 0.01). For all enzymes tested, the complex at different dose levels produced better effects than free quercetin at same doses. Thus the results obtained ascertain the superiority of quercetinphospholipid complex over free quercetin in terms of better free radical scavenging activity.
Full-Text [PDF 1162 kb]   (1047 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Maiti K, Mukherjee K, Gantait A, Nazeer Ahamed H, Saha B P, Kumar Mukherjee P. Enhanced Therapeutic Benefit of QuercetinPhospholipid Complex in Carbon Tetrachloride-Induced Acute Liver Injury in Rats: A Comparative Study. 3 2005; 4 (2) :84-0
URL: http://ijpt.iums.ac.ir/article-1-66-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 4, Issue 2 (11-2005) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4657