Opium dependence is one of the serious and multidimensional problems. Millions of people are opium addicts throughout the world. The aim of this study was to determine the risk factors causing relapse in opium addicts in Internally Displaced People (IDPs). This experiment was conducted in the Drug Detoxification and Health Welfare research center, Bannu, KPK, Pakistan. Sociodemographics characteristics of IDPs were studied in this retrospective cross-sectional study. Questionnaire was specifically designed and total 41 relapsed individual’s histories of post treated IDPs were studied. Percentage of factors causing relapse in IDPs included stress in 36.59% individuals, family conflicts 19.51%, friends 12.20%, work load stress 09.76%, body aches 07.31%, sexual satisfaction 09.76% and fun 04.87%. Average time of relapse in IDPs was 6 months. Results revealed that stress was the most notorious factor directing IDPs towards relapse. It is concluded that attention must be paid on the crucial factors of stress to avoid relapse associated with opium dependence such as, family conflicts, personal, occupational and economical status.