:: Volume 3, Issue 1 (5-2004) ::
3 2004, 3(1): 26-0 Back to browse issues page
The Pharmacokinetics of Rafoxanide following Single Dose Intravenous and Oral Administration in Goats
Swati Pal, Shiben Chandra Debnath, Shyamal Kumar Das, Animesh Kumar Chakraborty, Tapan Kumar Mandal
Abstract:   (912 Views)
The study was conducted to determine the plasma concentrations and pharmacokinetic parameters of rafoxanide after a single intravenous (10 mg/kg) and oral (22.5 mg/kg) administrations in black Bengal female goats. Maximum (87.63 11.71 mg/mL) and minimum (1.8 0.24 mg/mL) plasma concentrations of rafoxanide were recorded at 0.08 and 12 h respectively after i.v. administration. The elimination half life (t1/2b), total body clearance (ClB) and volume of distribution (Vdarea) values were 2.89 0.26 h, 0.05 0.002 L/kg/h and 0.19 0.02 L/kg respectively. An adequate plasma level of rafoxanide (14.63 2.12 mg/mL) was detected at 1h followed by gradual increase and peak concentration level (30.88 4.30 mg/mL) was recorded at 36 h after oral administration. The rate of absorption (Ka), elimination half life (t1/2 b), total body clearance (ClB) and volume of distribution (Vdarea) values were 0.07 0.009 h-1, 138.02 13.99 h, 0.003 0.0003 L/kg/h, and 0.57 0.06 L/kg respectively. Plasma protein binding percentages of rafoxanide varied from 81.06 to 92.28 and its association and dissociation constants were 1.26 107 0.18 107 L/mol and 0.83 10-7 0.12 10-7 mol/L respectively. On conclusion, rafoxanide is slowly absorbed from the gastrointestinal tract, slowly eliminated; highly protein bound and persists for long time in blood of goat.
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