2024-03-29T15:15:29+04:30 http://ijpt.iums.ac.ir/browse.php?mag_id=4&slc_lang=en&sid=1
4-26 2024-03-29 10.1002
Iranian Journal of Pharmacology and Therapeutics 3 9 10 7 2003 2 2 Mebudipine and Dibudipine: A Review Massoud Mahmoudian Based on QSAR studies two new DHP calcium-channel blockers, mebudipine and dibudipine, were synthesis and evaluated for their pharmacological activity in various tissues. These studies showed that, these compounds, with potency comparable or greater than that of nifedipine could relax the smooth muscles of various vascular tissues. Electrophysiological study showed that they antagonized calcium current in F1 neuronal soma membrane in Helix aspesa cells. Mebudipine has a greater time- and voltage-dependent inhibitory effect, as compared to nifedipine and this property could explain its prominent vaso-selective action. Based on pharmacokinetic studies it is found that these two compounds are extensively metabolized by hepatic cells and this will results in low bioavailability after oral administration. However, these newer 1,4-DHPs address the problem of the short half-life of nifedipine, and are metabolically stable, possess comparable pharmacological activity as nifedipine and are therefore suitable for further development as potential therapeutic alternatives to the existing 1,4-DHP calcium-channel blockers. Based on their vaso-selectivity and longer half-lives and negative chronotropic activity, It is concluded that they have a great potential for further development as a new drug. 2003 11 01 25 0 http://ijpt.iums.ac.ir/article-1-26-en.pdf
4-25 2024-03-29 10.1002
Iranian Journal of Pharmacology and Therapeutics 3 9 10 7 2003 2 2 Studies on Anti-inflammatory, Analgesic and Antipyretic Properties of Methanol Extract of Caesalpinia bonducella leaves in Experimental Animal Models Malaya Gupta Upal Kanti Mazumder Ramanathan Sambath Kumar Thangavel Siva Kumar The methanol extract of Caesalpinia bonducella leaves were investigated for anti-inflammatory, analgesic and antipyretic activity at the doses of 50, 100 and 200 mg/kg, body weight. The experimental paradigms used were carrageenan, dextran, histamine induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, while hot plate and acetic acid induced writhing methods were used to assess analgesic activity. Yeast-induced hyperpyrexia was used to evaluate the antipyretic activity. In acute phase inflammation, a maximum inhibition 50.6% (p < 0.05), 51.1% (p < 0.05) and 52.3% (p < 0.05) was noted at the dose of 200 mg/kg after 3 h of treatment with methanol extract of Caesalpinia bonducella (MECB) in carrageenan, dextran and histamine induced pedal edema respectively. In the chronic model (cotton pellet induced granuloma) the MECB (200 mg/kg) and standard drug (Indomethacin 10 mg/kg) showed decreased formation of granuloma tissue by 51.8% (p < 0.05) and 56.6% (p < 0.05) respectively. The extract also produced significant (p < 0.01) analgesic activity in both paradigms. In addition, MECB potentiated the morphine and aspirin induced analgesia. A significant (p < 0.01) reduction in hyperpyrexia in rat was also produced by the extract. This study exhibits that the methanol extracts of leaves of C. bonducella possess anti-inflammatory, analgesic and antipyretic activities. 2003 11 01 30 0 http://ijpt.iums.ac.ir/article-1-25-en.pdf
4-24 2024-03-29 10.1002
Iranian Journal of Pharmacology and Therapeutics 3 9 10 7 2003 2 2 Prostaglandins, Histamine and Platelet Activating Factor: Different Mediators in Dithranol-Induced Skin Damage Hamidreza Pazoki-Toroudi Nahid Abotaleb Morteza Tavakkoli Hoseini Yahya Dowlati Dithranol is a potent agent in treating psoriasis but its adverse effects on intact skin have limited its usage. There are many proposed mediators for its adverse effects including prostaglandins, histamine, platelet activating factor and free radicals. In this study we examined the effect of different agents (diazepam, terfenadine, indomethacin and garlic extract) on dithranol-induced skin damage in mice. Animals were treated with different drugs before local application of dithranol cream on the right buttock. Skin biopsy was performed after 48 or 96 hours. Diazepam (3 mg/Kg), terfenadine (20 mg/Kg), indomethacin (25 mg/Kg) and garlic extract (1% and 2%) were all capable of reducing dithranol-induced skin damage. It seems that the role of prostaglandins, histamine and platelet activating factor in the pathogenesis of dithranol-induced skin damage is inevitable. Garlic extract effect might be mediated by platelet activating factor but it needs further work to be proven. 2003 11 01 35 0 http://ijpt.iums.ac.ir/article-1-24-en.pdf
4-23 2024-03-29 10.1002
Iranian Journal of Pharmacology and Therapeutics 3 9 10 7 2003 2 2 Isolation, Identification and Antimicrobial Resistance Patterns of E. coli Isolated from Chicken Flocks Robab Rafiei Tabatabaei Azadeh Nasirian Fifty E. coli strains isolated from chicken flocks were analyzed to determine their resistance to antimicrobial agents used in Tehran poultry industry. By using Mast Diagnostic kit only O6 serotype was identified. Multiple resistance to antibiotics was observed in all isolates. The highest rate of resistance was against Tetracycline (94%), followed by Rifampicin (90%), and Oxytetracycline (80%). Fifty E. coli isolates showed 10 different patterns of resistance to the antimicrobial agents used in this study. The most common antimicrobial resistance pattern of these isolates was Enrofloxacin / Trimethoprim-Sulphamethoxazole / Tiamulin / Flumequine / Sulphadiazine / Oxytetracycline / Rifampicin. The present study confirms significant increase in the incidence of resistance in E. coli isolated from poultry which is probably due to increased use of antibiotics as feed additives for growth promotion and prevention of disease, resistance transfer among different bacteria and possible cross resistance between antibiotics used in domestic animals and those used in human medicine. 2003 11 01 39 0 http://ijpt.iums.ac.ir/article-1-23-en.pdf