en
jalali
1389
10
1
gregorian
2011
1
1
10
1
online
1
fulltext
en
Antibacterial activity and cytotoxicity screening of Sumatran Kaduk (Piper sarmentosum Roxb)
Phytochemical investigations of Piper sarmentosum Roxb., yielded four compounds; three amides, identified as 3-(3’,4’,5’-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4’-methoxyphenylpropanoyl) pyrrole, N -(3-phenylpropanoyl) pyrrole and a sterol namely β -sitosterol . 3-(4’-Methoxyphenylpropanoyl) pyrrole was found for the first time in this Piper species. All chemical constituents were tested for their antibacterial activity using disk diffusion method and cytotoxicity screening using sul-forhodamine B (SRB) assay. All of the compounds were found only active towards gram-positive bacteria except 3-(4’-methoxyphenylpropanoyl) pyrrole with no activity against both gram-positive and gram-negative bacteria. Meanwhile, the cytotoxicity screening using SRB assay indicated that none of these compounds was active as an anticancer agent.
1
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-233&slc_lang=en&sid=1
2017/11/13
1396/8/22
E.
Atiax
003194753284600790
003194753284600790
No
F.
Ahmad
003194753284600791
003194753284600791
No
H. M.
Sirat
003194753284600792
003194753284600792
No
D.
Arbain
003194753284600793
003194753284600793
No
V. Bhagwan
Badgujar
003194753284600794
003194753284600794
No
en
Comparative Investigation on Antimicrobial Property of Miliusa tomentosa Leaf Oil and Leaf Extract
Aqueous extract and volatile oil were obtained from Miliusa tomentosa by using soxhlet extractor and hydro distillation with a Clevenger-type apparatus respectively. The extract and volatile oil both were screened for Antimicrobial activity against different bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Klebsiella pncumoniae, Pseudomonas aeruginosa, Bacillus pumilis) and fungi (Candida albicans, Aspergillus niger, Fusarium monoliforme, Trichoderma viridae, Phanerochaete chrysosporium and Pcilomyces species) by cup plate diffusion method. Minimal Inhibitory Concentration (MIC) values of aqueous extract and volatile oil obtained were determined using modified cup plate method. The aqueous extract exhibited weak activity against all the bacteria and one fungi (Candida albicans), while volatile oil showed strong activity against most bacteria including Escherichia coli, Bacillus subtilis, Pseudommonas aeruginosa, Klebsiella pneumoni. Also, a moderate activity was seen against Staphylococcus aureus and Bacillus pumilis. It also showed strong activity against fungi like Candida albicans and Fusarium monoliforme, whereas moderate activity was observed on Aspergillus niger, Trichoderma viridae and the weak activity against the remaining fungi. It can be concluded that Miliusa tomentosa leaf volatile oil finds its use as broad-spectrum antimicrobial agent after extensive investigation, and this may provide a basis for the isolation of constituents of biological interest from Miliusa tomentosa for its potent activity.
7
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-232&slc_lang=en&sid=1
2017/11/132017/11/13
1396/8/22
V. Bhagwan
Badgujar
003194753284600788
003194753284600788
No
S. Javerilal
Surana
003194753284600789
003194753284600789
No
en
Botulinum Toxin Injections or Application of Splints: Impact on Spasticity, Range of Motion and Function of Upper Extremity in Chronic Stroke Patients
Spasticity or increase in muscle tone is one of the problems following stroke. Due to this increase in muscle tone, patients are confronted to problems in motor control and difficulties in activities of daily living and complications such as shortness and contracture. The aim of this study is to compare the effects of using splint or botulinum toxin injection on spasticity, range of motion and upper extremity function in a 3-month period. The method of this research study was a two comparison design, done in rehabilitation clinics in Tehran. At first, 50 patients with chronic stroke were selected and based on the inclusion criteria, a total of 28 stroke patients after completing the consent forms were entered to intervention groups of splint or botulinum toxin injection and they were followed up about 3 months. At last, 18 patients completed the study. Goniometery was the method to measure range of motion, and Modified Ashworth scale was used to examine the spasticity and the upper extremity function was scored based on Fugl-Meyer assessment. All outcome measures improved in each group, but the differences between two groups were not significant ( p value > 0.05). In this study, the effects of botulinum toxin injection and Volar-Dorsal Wrist/Hand Immobilization splint were not significantly different between the interventions in a 3-month follow-up.
11
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-231&slc_lang=en&sid=1
2017/11/132017/11/132017/11/13
1396/8/22
A.
Shamili
003194753284600783
003194753284600783
No
M.
Amini
003194753284600784
003194753284600784
No
B.
Forough
003194753284600785
003194753284600785
No
R.
Kazemi
003194753284600786
003194753284600786
No
M.
Qorbani
003194753284600787
003194753284600787
No
en
Pharmacokinetics and dosage regimen of cefpirome in febrile cross-bred calves
The pharmacokinetics of cefpirome after a single intravenous injection of 10 mg.kg -1 was studied in febrile cross-bred calves. E. coli endotoxin was administered intravenously to induce fever in calves. Blood samples were collected at different time intervals and cefpirome levels were estimated by using microbiological assay technique. Based on the plasma drug levels, the pharmacokinetic parameters were determined. Maximum concentration of cefpirome was attained at 1 min and the drug was detected above MIC in plasma up to 12 h after its administration. The values of t 1/2? , Vd area and AUC were 0.06 ± 0.003 h, 0.75 ± 0.02 L.kg -1 and 36.6 ± 0.82 ?g.ml -1 .h. The high values of t 1/2? (1.90 ± 0.03 h) and Cl B (0.27 ± 0.006 L.kg -1 .h -1 ) reflected rapid elimination and body clearance of the drug in febrile calves. The study suggested that cefpirome was rapidly distributed and rapidly eliminated in febrile crossbred calves.
17
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-229&slc_lang=en&sid=1
2017/11/132017/11/132017/11/132017/11/13
1396/8/22
N.
Rajput
003194753284600776
003194753284600776
No
V. Kumar
Dumka
003194753284600777
003194753284600777
No
Harpal Singh
Sandhu
003194753284600778
003194753284600778
No
en
Protective Effect of Methanolic Leaf Extract of Caesalpinia Bonduc (L.) on Gentamicin-Induced Hepatotoxicity and Nephrotoxicity in Rats
The present study was conducted to evaluate the protective effect of methanolic leaf extract of Caesalpinia bonduc (L.) on gentamicin-induced hepatotoxicity and nephrotoxicity in rats . A control group (saline, group I, n = 6) was compared with rats administrated 80 mg/kg gentamicin, once daily for 7 days (groups II, III and IV). The effect of methanolic leaf extract of Caesalpinia bonduc (group III and IV) at a dose level of 250 mg/kg and 500 mg/kg was compared in gentamicin-induced hepatotoxicity and nephrotoxicity. The activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), bilirubin, and total protein the values of urea, sodium, potassium and chloride were significantly increased in rats exposed to gentamicin. Moreover, administration of gentamicin resulted in damage to liver and kidney structures. Administration of methanolic extract of C.bonduc before gentamicin exposure prevented severe alterations of biochemical parameters and disruptions of liver and kidney structures. In conclusion, this study obviously demonstrated that pretreatment with methanolic extract of C.bonduc significantly attenuated the physiological and histopathological alterations induced by gentamicin. Also, the present study identifies new areas of research for development of better therapeutic agents for liver, kidney, and other organs dysfunctions and diseases.
21
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-230&slc_lang=en&sid=1
2017/11/132017/11/132017/11/132017/11/132017/11/13
1396/8/22
A. Ali
Noorani
003194753284600779
003194753284600779
No
K.
Gupta
003194753284600780
003194753284600780
No
K.
Bhadada
003194753284600781
003194753284600781
No
M. K.
KALE
003194753284600782
003194753284600782
No
en
In Vivo and In Vitro Studies on Neutralizing Effects of Acorus calamus and Withania somnifera root extracts against Echis carinatus venom
Neutralization effects of Acorus calamus and Withania somnifera root extracts were tested against Echis carinatus venom. Both plant extracts were effectively neutralized the various pharmacological activities induced by Echis carinatus venom. About 0.14 mg of Acorus calamus and 0.16 mg of Withania somnifera root extracts were able to completely neutralize the lethal activity of 2LD 50 of Echis carinatus venom. Various pharmacological activities like haemorrhagic, coagulant, edema and phospholipase activities were effectively neutralized by both plant extracts. The above observations confirmed that both plant extracts possess potent snake venom neutralizing compounds, which inhibit the activity of Echis carinatus venoms.
26
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-228&slc_lang=en&sid=1
2017/11/132017/11/132017/11/132017/11/132017/11/132017/11/13
1396/8/22
S.
Meenatcisundaram
003194753284600774
003194753284600774
No
M.
Sindhu
003194753284600775
003194753284600775
No
en
Analgesic, Anti-Inflammatory and Anti-arthritic Activity of Newly-Synthesized Bicyclothieno 1, 2, 3 – Triazines
The novel bicyclo thieno 1, 2, 3-triazines (BTT) namely BTT-1, BTT-2, BTT-3 and BTT-4 were evaluated for analgesic anti-inflammatory and antiarthritic activity. Analgesic and anti-inflammatory activity was evaluated using hot plate test , formalin induced paw licking test and formalin induced paw edema test respectively, complete fruend’s adjuvant (CFA) induced arthritis model was used for antiarthrtic activity. All test drugs have showed significant analgesic activity by increasing the reaction latency time in hot plate test and decreasing the number of lickings in formalin test, BTT-3 was found to be effective in both early and late phase, while all other test drugs were found to be effective only in late phase of nociception. In anti-inflammatory studies, the BTT-3 (25 and 50mg/kg, i.p.) had significantly reduced the formalin induced paw edema. In CFA induced arthritis models, the BTT-3 has showed activity from the 4 th day of the treatment, while all the other test drugs have showed significant inhibition of CFA induced paw edema from the 7 th day of the treatment by decreasing the elevated levels of WBC, % Hb, ESR, along with decreasing the serum levels of C-reactive protein (CRP) and Rheumatoid factor. In conclusion all test drugs were found to possess very good analgesic, anti-inflammatory and antiarthritic activity and BTT-3 was found to be more potent compare to other compounds.
31
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-227&slc_lang=en&sid=1
2017/11/132017/11/132017/11/132017/11/132017/11/132017/11/132017/11/13
1396/8/22
G.L.
Viswanatha
003194753284600769
003194753284600769
No
N.
Akinapally
003194753284600770
003194753284600770
No
N.
Krishnadas
003194753284600771
003194753284600771
No
S.
Rangappa
003194753284600772
003194753284600772
No
S.
Janardhanan
003194753284600773
003194753284600773
No
en
Protective Effect of Tahitian Noni Juice on the Reproductive Functions of Male Wistar Rats Traeted with Cyclophosphamide
The effects of Tahitian noni juice (TNJ), vitamin C and vitamin E on male reproductive functions in cyclophosphamide-treated wistar rats were compared. Thirty five male wistar rats with mean body weight of 180 ± 24.3 g were randomly divided into five groups. Group one were treated with cyclophosphamide (50 mg/kg, i.p.) while, group two were treated with TNJ (10 ml/kg, i.p.) and cyclophosphamide. Group three were treated with TNJ (10 ml/kg, i.p.) alone. Group four and five were treated with cyclophosphamide and either of vitamin C (100 mg/kg) or E (1 mg/kg) respectively. All drugs were administered for four weeks. In this study, mean weight gain, sperm motility (SM), live-dead ratio (LDR), epididymal sperm counts (ESC), percentage sperm abnormality, as well as, testicular histological changes were determined. Data were expressed as mean ± standard deviation. The ESC, SM and LDR were compared with analysis of variance (ANOVA). Median score for the histologic changes was analyzed using Wilcoxon sign rank test. The mean weight gain was higher in Groups 2 and 3 compared with other groups ( p <0.05). Similarly, the SM was higher in rats treated with TNJ compared with other groups ( p <0.001). The LDR, ESC, and testicular histologic scores did not differ between the five groups of rats. However, the percentage sperm abnormality was lower in groups 2 and 3 ( p <0.05). In conclusion, TNJ improved weight gain and protected against adverse effect of cyclophosphamide on sperm motility and abnormalities.
39
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-226&slc_lang=en&sid=1
2017/11/132017/11/132017/11/132017/11/132017/11/132017/11/132017/11/132017/11/13
1396/8/22
AJADI ADETOLA
ABIDEMI
003194753284600768
003194753284600768
No
en
Potential Drug Interactions in War-Injured Veterans
Drug-drug interaction (DDI) is one of the most important problems in the treatment of patients suffering from different chronic intractable diseases. The war-injured veterans are one of the groups that are prone to chronic refractory diseases. This investigation was conducted on war-injured veterans treated in a multi-disciplinary clinic in Tehran. Using Poisson model, a total of 150 patients was collected from the patients treated in a multidisciplinary clinic during three months. The prescriptions were processed using the Drug Interactions Checker. Drug interactions in these patients were categorized to three levels, i.e. mild, moderate, and severe. Drug interactions were identified in 148 patients with different intensity. Based on FDA classification, the mild, moderate, and severe DDI were observed in 56 (37.3%), 139 (92.7%), and 74 (49.3%) patients, respectively. The total number of drug interactions was 1239 in these patients. The most common type of DDI was observed in the patients who received anti-depression drugs. This study shows that war-injured veterans are a group of patients with high risk of drug interaction. The results indicate the necessity and importance of devising some guidelines to prevent or at least decrease the drug interactions in war-injured veterans with chronic refractory diseases.
44
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-225&slc_lang=en&sid=1
2017/11/132017/11/132017/11/132017/11/132017/11/132017/11/132017/11/132017/11/132017/11/13
1396/8/22
M.
Gharakhani
003194753284600759
003194753284600759
No
Soodeh
Razeghi jahromi
003194753284600760
003194753284600760
No
H.
Sadeghian
003194753284600761
003194753284600761
No
S.
Faghihzadeh
003194753284600762
003194753284600762
No
H.
Kazemi
003194753284600763
003194753284600763
No
J.
Arabkheradmand
003194753284600764
003194753284600764
No
P.
Koulivand
003194753284600765
003194753284600765
No
Leila
Bayan
003194753284600766
003194753284600766
No
A.
Gorji
003194753284600767
003194753284600767
No