2
1
3
Literature & Humanities
http://ijpt.iums.ac.ir
1
admin
9
10
8
7
14
8888
13
en
jalali
1384
8
1
gregorian
2005
11
1
4
2
online
1
fulltext
en
Enhanced Therapeutic Benefit of QuercetinPhospholipid Complex in Carbon Tetrachloride-Induced Acute Liver Injury in Rats: A Comparative Study
پژوهشي
Research Article
Quercetin is a typical flavonoid with diverse biological effects, attributable to its free radical scavenging activity. Bioavailability of quercetin aglycone and its glycosides is an important factor for its antioxidant activity in vivo. A severe limitation exists and is imputable to very poor absorption of quercetin when administered orally. To overcome this limitation, development of a value added herbal formulation in combination with phospholipids has been made which has better absorption and utilization profiles. Free radical scavenging activity of quercetinphospholipid complex (equivalent to quercetin 10mg and 20 mg/kg body wt.) and free quercetin (10 mg and 20 mg/kg body wt.) was evaluated in oxidative stress condition in albino rats induced by carbon tetrachloride intoxication. The degree of protection of liver was estimated by evaluating status of enzymes like super oxide dismutase (SOD), catalase; lipid peroxidation profile in terms of thiobarbituric acid reactive substances (TBARS), reduced glutathione, glutathione peroxidase, glutathione reductase and glutathioneStransferase. Quercetinphospholipid complex restored the reduced enzyme levels of liver glutathione system as well as impaired levels of other enzymes which are significant with respect to carbon tetrachloride treated group (p < 0.05 and < 0.01). For all enzymes tested, the complex at different dose levels produced better effects than free quercetin at same doses. Thus the results obtained ascertain the superiority of quercetinphospholipid complex over free quercetin in terms of better free radical scavenging activity.
84
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-76&slc_lang=en&sid=1
Kuntal
Maiti
1003194753284600230
1003194753284600230
No
Kakali
Mukherjee
1003194753284600231
1003194753284600231
No
Arunava
Gantait
1003194753284600232
1003194753284600232
No
Haja
Nazeer Ahamed
1003194753284600233
1003194753284600233
No
Bishnu Pada
Saha
1003194753284600234
1003194753284600234
No
Pulok
Kumar Mukherjee
1003194753284600235
1003194753284600235
No