2
1
3
Literature & Humanities
http://ijpt.iums.ac.ir
1
admin
9
10
8
7
14
8888
13
en
jalali
1397
3
1
gregorian
2018
6
1
16
1
online
1
fulltext
en
Inhibitory effect of concomitant administration of Zataria multiflora Boiss. against oxidative damage-induced by sub-acute exposure to arsenic in rats
Toxicology
پژوهشي
Research Article
<div style="text-align: justify;">To evaluate the protective effect of Zataria multiflora boiss. (Zm) extract against arsenic-induced oxidative damage in rats. Rats were orally treated with various doses of Zm (200, 400, and 600 mg/kg) and sodium arsenite (5.5 mg/ kg), alone or in combination, once daily for 30 consecutive days. Twenty-four hours after the last dose, rats were euthanized, and biochemical studies were conducted on their blood samples. Sub-acute exposure to the sub-lethal dose of arsenic markedly altered the blood levels of several biomarkers associated with oxidative stress. Treatment with Zm significantly inhibited the elevation of lipid peroxidation and protein carbonylation and the depletion in total antioxidant capacity in plasma. In addition, Zm effectively increased the total antioxidant capacity of plasma in a dosedependent manner in control and arsenic-treated groups. The results reveal that Zm as an antioxidative medicinal plant reduces oxidative damages induced by arsenic in the doses much lower than the lethal dose (2-4 gr/kg). Since Zm is a safe herbal<br>
drug routinely used as condiment, it can be used as a good supplement for reducing toxicity of low dose of arsenic in long-term exposure. Further studies on human environmentally exposed to arsenic through drinking water and food are proposed to find out effective dose in human.</div>
Arsenic, sodium arsenite, herbal supplement, herbal medicine, Zataria multiflora
1
5
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-123-1&slc_lang=en&sid=1
FARZAD
NASRPOUR
2480346@gmail.com
10031947532846001645
10031947532846001645
Yes
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
FARIBA
SHARIFIFAR
fa.sharififar@gmail.com
10031947532846001646
10031947532846001646
No
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
MARZIEH
BARFE
marzieh.barfe@yahoo.com
10031947532846001647
10031947532846001647
No
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
MOHAMMAD
MEHDIPOUR
eankpen2008@yahoo.com
10031947532846001648
10031947532846001648
No
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
SOMAYYEH
KARAMI-MOHAJERI
somayyehkarami@gmail.com
10031947532846001649
10031947532846001649
No
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran