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Literature & Humanities
http://ijpt.iums.ac.ir
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admin
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8888
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en
jalali
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gregorian
2018
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Protection of alloxan monohydrate-induced testicular toxicity by Gundelia tournefortii aerial parts aqueous extract in male mice.
Toxicology
پژوهشي
Research Article
<div style="text-align: justify;"><strong>ABSTRACT </strong><br>
For a long period, ethno medicinal plants have been a valuable source of natural products for maintaining human health, especially in the last decade, with more intensive studies for natural therapies. The use of ethno medicinal plant for pharmaceutical purposes has gradually increased in Iran. <em>Gundelia tournefortii </em>has been used as an antibacterial, anti-fungal, antipyretic, anti-inflammatory, and antioxidant agent in Iran. In the recent examination, the testicular protective effect of <em>G. tournefortii </em>aerial parts aqueous extract on diabetic mice has been evaluated. Seventy mice were used and diabetes was induced by administration of 150 mg/kg of alloxan monohydrate intraperitoneally in 60 mature male mice and they were randomly divided into six groups. The treatment groups received glibenclamide 10 mg/kg and 5, 10, 20 and 40 mg/kg of <em>G. tournefortii </em>through gavage for 20 days. Also, one group was considered as the non-diabetic control. At 20<sup>th</sup> day, the mice were killed, dissected, then blood and testis samples were collected for biochemical and stereological parameters analysis. The data were analyzed by SPSS-21 software. <em>G. tournefortii</em> at all doses (especially GT40) and glibenclamide significantly (p≤0.05) ameliorated the concentrations of fasting blood glucose, testosterone, superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase. Also, multiple doses of <em>G. tournefortii</em> (especially GT40) and glibenclamide increased the weight and volume of the testis, the volumes of the tubule and interstitial tissue, the length and diameter of the tubule, the height of the germinal epithelium, and the number of the Leydig cell compared to the diabetic untreated group. According to the obtained results, <em>G. tournefortii </em>aerial parts aqueous extract can regulate the concentrations of biochemical parameters and inhibit testicular damages in alloxan monohydrate induced diabetic mice. It seems that <em>G. tournefortii </em>can be offered as a testicular protective supplement or drug for prevention, control, and treatment of testicular toxicity in diabetic patients.</div>
Gundelia tournefortii, Aqueous extract, Testicular toxicity, Alloxan monohydrate.
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http://ijpt.iums.ac.ir/browse.php?a_code=A-10-120-4&slc_lang=en&sid=1
SAMANEH
GOORANI
samanegoorani@ut.ac.ir
10031947532846001678
10031947532846001678
No
Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Mohammad KAZEM
KOOHI
mkkoohi@yahoo.com
10031947532846001679
10031947532846001679
No
Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
NILOOFAR
SEYDI
n.seydi@yahoo.com
10031947532846001680
10031947532846001680
No
Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
AKRAM
ZANGENEH
akramzangeneh@yahoo.com
10031947532846001681
10031947532846001681
Yes
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.
MOHAMMAD MAHDI
ZANGENEH
m.mahdizangeneh@gmail.com
10031947532846001682
10031947532846001682
No
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.