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Literature & Humanities
http://ijpt.iums.ac.ir
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admin
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8888
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en
jalali
1397
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gregorian
2018
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online
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fulltext
en
Ameliorative property of the ethanolic extract of Tragopogon graminifolius DC. on carbon tetrachloride-induced hepatotoxicity in mice: A pharmacological examination
Toxicology
پژوهشي
Research Article
<strong>ABSTRACT </strong><br>
Hepatotoxicity is the most common disorder with severe effects on quality of life. <em>Tragopogon graminifolius</em> DC. has been used in Iran as an astringent and bleeding inhibitor, wound healer and gastro-protector agent. To our knowledge, there are little evidence at hand on hepatoprotective activity of<em> T. graminifolius</em>. The present study was carried out to assess hepatoprotective property of <em>T. graminifolius</em> ethanolic extract on carbon tetrachloride (CCl<sub>4</sub>) induced hepatotoxicity in mice for 45 consecutive days. Fifty male mice were divided into five groups (n=10). Group 1 (control) received 1 ml/kg olive oil intraperitoneally (i.p.) and distilled water orally; Group 2 (untreated) received CCl<sub>4</sub> (50% in olive oil, 1 ml/kg; i.p.); Groups 3, 4 and 5 received CCl<sub>4</sub> and 30, 90 and 270 mg/kg of <em>T. graminifolius</em> (T30, T90 and T270), respectively. At 45<sup>th</sup> day, the mice were killed, dissected, then blood and liver samples were collected for biochemical and stereological parameters analysis. Biochemically, <em>T. graminifolius</em> at all doses (especially T270) could significantly (<em>p≤</em>0.05) reduce the raised levels of cholesterol, low density lipoprotein (LDL), triglyceride, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), total and conjugated bilirubin, and increase the decreased levels of high density lipoprotein (HDL), total protein, albumin, superoxide dismutase (SOD) and catalase (CAT). Stereologically, different doses of <em>T. graminifolius</em> (especially T270) decreased the weight and volume of the hepatic structures as compared to the untreated group significantly (p≤0.05). The obtained results indicate that<em> T. graminifolius </em>ethanolic extract, potential applications as a therapeutical supplement or medicine, after confirming clinical trial studies.<br>
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Tragopogon graminifolius DC., ethanolic extract, hepatoprotective property, carbon tetrachloride
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http://ijpt.iums.ac.ir/browse.php?a_code=A-10-120-2&slc_lang=en&sid=1
SAMANEH
GOORANI
samanegoorani@ut.ac.ir
10031947532846001617
10031947532846001617
No
Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
MOHAMMAD KAZEM
KOOHI
mkkoohi@yahoo.com
10031947532846001618
10031947532846001618
No
Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
AKRAM
ZANGENEH
akramzangeneh@yahoo.com
10031947532846001619
10031947532846001619
No
Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
FARIBA
HOSSEINI
fariba.hosseini2010@gmail.com
10031947532846001620
10031947532846001620
No
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.
MOHAMMAD MAHDI
ZANGENEH
m.mahdizangeneh@gmail.com
10031947532846001621
10031947532846001621
Yes
Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.